INFLUENCE OF THIOCOMPOUNDS ON THE METABOLISM OF N-NITROSODIETHYLAMINE

被引：9

作者：

FRANK, N ^{[1
]}

BERTRAM, B ^{[1
]}

FREI, E ^{[1
]}

HADJIOLOV, D ^{[1
]}

WIESSLER, M ^{[1
]}

机构：

[1] CTR ONCOL, SOFIA DARVENITZA, BULGARIA

来源：

CARCINOGENESIS | 1988年 / 9卷 / 07期

关键词：

D O I：

10.1093/carcin/9.7.1303

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Diethyldithiocarbaminate (DDTC), mercaptoethanesulfonate (MESNA) and ethylxanthate (PEX) were tested for their influence on N-nitrosodiethylamine (NDEA) metabolism. The exhalation rate of 14CO2 released from [14C]NDEA was decreased by PEX, but not by MESNA or DDTC. The sulfur compounds led to an increased excretion of unchanged NDEA in urine in the order PEX > DDTC > > MESNA. The activity of NDEA-deethylase in liver microsomal system was decreased only after DDTC or PEX treatment. Glutathione content and glutathione-S-transferase activity were not affected significantly by any of the tested compounds. NDEA-induced single-strand breaks in liver cell DNA were inhibited after PEX treatment.

引用

页码：1303 / 1306

页数：4

共 22 条

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