THE PHOTOKILLING OF BLADDER-CARCINOMA CELLS-INVITRO BY PHENOTHIAZINE DYES

被引：45

作者：

FOWLER, GJS ^{[1
]}

REES, RC ^{[1
]}

DEVONSHIRE, R ^{[1
]}

机构：

[1] ROYAL HALLAMSHIRE HOSP,DEPT EXPTL & CLIN MICROBIOL,TUMOUR BIOL & IMMUNOL SECT,SHEFFIELD S10 2RX,S YORKSHIRE,ENGLAND

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1990年 / 52卷 / 03期

关键词：

D O I：

10.1111/j.1751-1097.1990.tb01790.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract— The potential photodynamic therapy photosensitizers Methylene Blue, Azure C, Methylene Violet, Thionine, Methylene Green, Haematoporphyrin, Nile Blue A, chloroaluminium phthalocyanine and bis‐aluminium phthalocyanine were examined for their photoeffects and dark toxicity against a human superficial bladder carcinoma cell‐line. By examination of [3H]thymidine uptake into dye‐treated cells after irradiation with a copper‐vapour pumped dye laser, it was found that Methylene Blue was the most phototoxic and dark toxic of all the dyes tested, suggesting that the dye might be of some use as a topically applied photodrug for use in photodynamic therapy of superficial or early‐recurring carcinomas. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：489 / 494

页数：6

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