PHOTOSENSITIZATION IS REQUIRED FOR INACTIVATION OF EQUINE INFECTIOUS-ANEMIA VIRUS BY HYPERICIN

被引：136

作者：

CARPENTER, S ^{[1
]}

KRAUS, GA ^{[1
]}

机构：

[1] IOWA STATE UNIV SCI & TECHNOL,DEPT CHEM,AMES,IA 50011

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1991年 / 53卷 / 02期

关键词：

D O I：

10.1111/j.1751-1097.1991.tb03919.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hypericin, a photoreactive polycyclic quinone, was found to dramatically reduce infectivity of cell-free stocks of equine infectious anemia virus. However, the antiviral activity of hypericin was completely dependent on the presence of light. Short periods of photosensitization resulted in a partial loss of reverse transcriptase activity and complete inhibition of viral infectivity. These results suggest that the photodynamic effect of hypericin interferes with more than one state in the virus replication cycle.

引用

页码：169 / 174

页数：6

共 20 条

[1] ALKALINE ELUTION STUDIES OF HEMATOPORPHYRIN-DERIVATIVE PHOTOSENSITIZED DNA DAMAGE AND REPAIR IN CHINESE-HAMSTER OVARY CELLS [J].

BLAZEK, ER ;

HARIHARAN, PV .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1984, 40 (01) :5-13

[2]

BOEGHEIM JPJ, 1985, PHOTODYNAMIC THERAPY, P133

[3] ROLE OF THE HOST IMMUNE-RESPONSE IN SELECTION OF EQUINE INFECTIOUS-ANEMIA VIRUS VARIANTS [J].

CARPENTER, S ;

EVANS, LH ;

SEVOIAN, M ;

CHESEBRO, B .

JOURNAL OF VIROLOGY, 1987, 61 (12) :3783-3789

[4] CHANGE IN HOST-CELL TROPISM ASSOCIATED WITH INVITRO REPLICATION OF EQUINE INFECTIOUS-ANEMIA VIRUS [J].

CARPENTER, S ;

CHESEBRO, B .

JOURNAL OF VIROLOGY, 1989, 63 (06) :2492-2496

[5] PHOTODYNAMIC INACTIVATION OF SIMIAN IMMUNODEFICIENCY VIRUS [J].

CHANH, TC ;

ALLAN, JS ;

MATTHEWS, JL ;

SOGANDARESBERNAL, F ;

JUDY, MM ;

SKILES, H ;

LEVESON, J ;

MARENGOROWE, A ;

NEWMAN, JT .

JOURNAL OF VIROLOGICAL METHODS, 1989, 26 (01) :125-131

[6]

DANIEL K, 1949, HYPPOKRATES, V20, P526

[7] HYPERICIN AND ITS PHOTODYNAMIC-ACTION [J].

DURAN, N ;

SONG, PS .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1986, 43 (06) :677-680

[8] ISOLATION AND PROPERTIES OF MOLONEY MURINE LEUKEMIA-VIRUS MUTANTS - USE OF A RAPID ASSAY FOR RELEASE OF VIRION REVERSE-TRANSCRIPTASE [J].

GOFF, S ;

TRAKTMAN, P ;

BALTIMORE, D .

JOURNAL OF VIROLOGY, 1981, 38 (01) :239-248

[9] HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-III SHARES SEQUENCE HOMOLOGY WITH A FAMILY OF PATHOGENIC LENTIVIRUSES [J].

GONDA, MA ;

BRAUN, MJ ;

CLEMENTS, JE ;

PYPER, JM ;

WONGSTAAL, F ;

GALLO, RC ;

GILDEN, RV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (11) :4007-4011

[10]

HUDSON JB, 1990, AM SOC PHOT

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