LONG-TERM STABILITY OF HEPARIN-SURFACE-MODIFIED INTRAOCULAR LENSES INVIVO

被引：16

作者：

LARSSON, R ^{[1
]}

SELEN, G ^{[1
]}

FORMGREN, B ^{[1
]}

HOLST, A ^{[1
]}

机构：

[1] KABI PHARM THERAPEUT AB,UPPSALA,SWEDEN

来源：

JOURNAL OF CATARACT AND REFRACTIVE SURGERY | 1992年 / 18卷 / 03期

关键词：

HEPARIN SURFACE MODIFICATION; IMPLANTATION; INTRAOCULAR LENS; RABBIT; STABILITY;

D O I：

10.1016/S0886-3350(13)80901-7

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

In vivo long-term stability of intraocular lens surfaces, modified by immobilized heparin, was studied. Lenses were implanted in the anterior chamber of rabbits and analyzed for surface concentration of heparin after varying periods of time up to two years. A new method using adsorption of 125iodine-labeled protamine was developed for quantitative measurements of immobilized heparin. Another assay, based on a monoclonal antibody against heparin, was also included. The study showed that surface-immobilized heparin did not degrade or desorb to any measurable degree during a two-year follow-up.

引用

页码：247 / 251

页数：5

共 6 条

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[2]

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[3]

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[4]

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[5]

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[6]

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