BIOLOGICAL CONSEQUENCES OF GENE-REGULATION AFTER IONIZING-RADIATION EXPOSURE

被引：162

作者：

WEICHSELBAUM, RR

HALLAHAN, DE

SUKHATME, V

DRITSCHILO, A

SHERMAN, ML

KUFE, DW

机构：

[1] UNIV CHICAGO HOSP & CLIN,DEPT RADIAT & CELLULAR ONCOL,CHICAGO,IL 60637

[2] UNIV CHICAGO HOSP & CLIN,DEPT MED,CHICAGO,IL 60637

[3] GEORGETOWN UNIV,MED CTR,WASHINGTON,DC 20007

[4] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,CLIN PHARMACOL LAB,BOSTON,MA 02115

来源：

JOURNAL OF THE NATIONAL CANCER INSTITUTE | 1991年 / 83卷 / 07期

关键词：

D O I：

10.1093/jnci/83.7.480

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ionizing radiation is a ubiquitous environmental mutagen and carcinogen widely used in cancer therapy. However, little is known about the induction of cellular signaling events and specific gene expression after radiation exposure. We review the accumulating evidence that ionizing radiation induces signal transduction pathways involving activation of protein kinase C and a program of genetic events that may contribute to the biological effects of x rays.

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页码：480 / 484

页数：5

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