NEUROCHEMICAL CHANGES OF LONG-TERM ADRENALECTOMY IN RAT-BRAIN - EFFECTS ON NEUROTRANSMITTER AMINO-ACIDS

被引：2

作者：

ZONTA, N ^{[1
]}

FERRARIO, P ^{[1
]}

DIGIULIO, AM ^{[1
]}

ZECCA, L ^{[1
]}

GORIO, A ^{[1
]}

MANTEGAZZA, P ^{[1
]}

机构：

[1] CNR,ITBA,I-20131 MILAN,ITALY

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE | 1992年 / 10卷 / 05期

关键词：

D O I：

10.1016/0736-5748(92)90034-W

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The levels of five amino acids together with glutamine synthetase activity, were measured in brain regions of rats with bilateral adrenalectomy, performed in newly weaning rats on postnatal day 22 and sacrificed 3 months later. Adrenalectomy caused a general decrease of glutamine concentration in three hippocampal regions (CA1-CA2, CA3, CA4-dentate gyrus), in hypothalamus, striatum and cerebellum. This reduction, which was particularly significant in hippocampus and cerebellum, was paralleled by a decrease of glutamine synthetase activity. Treatment with corticosterone reversed the effect of adrenalectomy. Little or no change was observed in the tissue levels of taurine, aspartic, glutamic or gamma-amino butyric acids.

引用

页码：439 / 445

页数：7

共 32 条

[1] GRANULE CELL GENESIS IN THE HIPPOCAMPUS OF RATS TREATED NEONATALLY WITH HYDROCORTISONE [J].