LONGITUDINAL CHANGES IN PROTON MAGNETIC-RESONANCE SPECTROSCOPY IN CEREBRAL INFARCTION

被引：67

作者：

HOUKIN, K ^{[1
]}

KAMADA, K ^{[1
]}

KAMIYAMA, H ^{[1
]}

IWASAKI, Y ^{[1
]}

ABE, H ^{[1
]}

KASHIWABA, T ^{[1
]}

机构：

[1] KASHIWABA NEUROSURG HOSP,SAPPORO,JAPAN

来源：

STROKE | 1993年 / 24卷 / 09期

关键词：

CEREBRAL INFARCTION; LACTATES; SPECTROSCOPY; NUCLEAR MAGNETIC RESONANCE;

D O I：

10.1161/01.STR.24.9.1316

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose: Proton magnetic resonance spectroscopy has revealed changes in lactate and N-acetyl-aspartate in acute cerebral infarction. However, the details of these drastic changes and subsequent chronic changes have not been clarified. The purpose of this study was to disclose longitudinal changes in spectra seen in proton magnetic resonance spectroscopy. Methods: Six patients with completed cerebral infarction were examined longitudinally with localized proton magnetic resonance spectroscopy. Results: (1) In the acute stage (within 2 days after onset), two drastic changes were observed: N-acetyl-aspartate decreased rapidly and severely within 2 days after onset, and lactate increased immediately and reached a high level in the acute stage after onset. (2) In the chronic stage (more than 1 month after onset), two features were observed: lactate, which had increased in the acute stage, remained high for more than 1 month, and other signals such as those of N-acetyl-aspartate, choline, and phosphocreatine/creatine decreased dramatically. Conclusions: These results suggest that N-acetyl-aspartate and lactate as revealed by proton magnetic resonance spectroscopy can be useful indicators of the ischemic damage to the brain in clinical cases of cerebral infarction.

引用

页码：1316 / 1321

页数：6

共 20 条

[1] CHRONIC ADULT CEREBRAL INFARCTION STUDIED BY PHOSPHORUS NMR-SPECTROSCOPY [J].