CYCLODIDEMNAMIDE - A NEW CYCLIC HEPTAPEPTIDE FROM THE MARINE ASCIDIAN DIDEMNUM MOLLE

被引：39

作者：

TOSKE, SG ^{[1
]}

FENICAL, W ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO, SCRIPPS INST OCEANOG, LA JOLLA, CA 92093 USA

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 46期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0040-4039(95)01806-S

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cyclodidemnamide (1), a new cyclic heptapeptide, has been isolated from the marine ascidian Didemnum molle collected in the Philippine Islands. The structure of the new, weakly cytotoxic, heptapeptide was unambiguously assigned using comprehensive NMR analysis in combination with hydrolysis and chiral GC-MS analysis of its component amino acids. Computer analysis of 1 led to assignment of a solution conformation that fully rationalized the nOe correlations and shielding effects observed by H-1 NMR.

引用

页码：8355 / 8358

页数：4

共 3 条

[1] STUDIES OF AUSTRALIAN ASCIDIANS .4. MOLLAMIDE, A CYTOTOXIC CYCLIC HEPTAPEPTIDE FROM THE COMPOUND ASCIDIAN DIDEMNUM MOLLE
CARROLL, AR
BOWDEN, BF
COLL, JC
HOCKLESS, DCR
SKELTON, BW
WHITE, AH
[J]. AUSTRALIAN JOURNAL OF CHEMISTRY, 1994, 47 (01) : 61 - 69
[2] Pretsch E., 1989, SPECTRAL DATA STRUCT
[3] CYCLIC-PEPTIDES FROM THE ASCIDIAN LISSOCLINUM-PATELLA - CONFORMATIONAL-ANALYSIS OF PATELLAMIDE-D BY X-RAY-ANALYSIS AND MOLECULAR MODELING
SCHMITZ, FJ
KSEBATI, MB
CHANG, JS
WANG, JL
HOSSAIN, MB
VANDERHELM, D
ENGEL, MH
SERBAN, A
SILFER, JA
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (14) : 3463 - 3472

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