THE RELIABILITY OF OPTIMIZATION UNDER DOSE-VOLUME LIMITS

被引:15
作者
LANGER, M
BROWN, R
KIJEWSKI, P
HA, C
机构
[1] JOINT CTR RADIAT THERAPY,BOSTON,MA
[2] SOFTBRIDGE MICROSYST,CAMBRIDGE,MA
来源
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1993年 / 26卷 / 03期
基金
美国国家科学基金会;
关键词
OPTIMIZATION; COMPUTER TREATMENT PLANNING; DOSE-VOLUME LIMITS;
D O I
10.1016/0360-3016(93)90972-X
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: An optimization algorithm improves the distribution of dose among discrete points in tissues, but tolerance depends on the distribution of dose across a continuous volume. This report asks whether an exact algorithm can be completed when enough points are taken to accurately model a dose-volume constraint. Methods and Materials: Trials were performed using a 3-dimensional model of conformal therapy of lung cancer. Trials were repeated with different limits placed on the fraction of lung which could receive > 20 Gy. Bounds were placed on cord dose and target dose inhomogeneity. A mixed integer algorithm was used to find a feasible set of beam weights which would maximize tumor dose. Tests of feasibility and optimality are introduced to check the solution accuracy. Results: Solutions were optimal for points used to model tissues. An accuracy of 3-4% in a volume condition could be obtained with models of 450-600 points. The error improved to 2% with 800 points to model the lung. Solution times increased six-fold at this level of accuracy. Conclusion: The mixed integer method can find optimum weights which respect dose-volume conditions in usually acceptable times. If constraints are violated by an excessive amount, the optimization model should be rerun with more points.
引用
收藏
页码:529 / 538
页数:10
相关论文
共 23 条
[1]   METHOD OF LINEAR PROGRAMMING APPLIED TO RADIATION TREATMENT PLANNING [J].
BAHR, GK ;
KEREIAKES, JG ;
HORWITZ, H ;
FINNEY, R ;
GALVIN, J ;
GOODE, K .
RADIOLOGY, 1968, 91 (04) :686-+
[2]  
CHOI N C, 1985, Cancer Treatment Symposia, V2, P119
[3]   PRESCRIPTION, PRECISION, AND DECISION IN TREATMENT PLANNING - KEYNOTE ADDRESS [J].
DUTREIX, A .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1987, 13 (09) :1291-1296
[4]   TOLERANCE OF NORMAL TISSUE TO THERAPEUTIC IRRADIATION [J].
EMAMI, B ;
LYMAN, J ;
BROWN, A ;
COIA, L ;
GOITEIN, M ;
MUNZENRIDER, JE ;
SHANK, B ;
SOLIN, LJ ;
WESSON, M .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1991, 21 (01) :109-122
[5]   SEMIAUTOMATIC OPTIMIZATION OF EXTERNAL BEAM RADIATION TREATMENT PLANNING [J].
HODES, L .
RADIOLOGY, 1974, 110 (01) :191-196
[6]   CCRT FOR NON-SMALL-CELL LUNG-CANCER - SENSITIVITY OF CLINICAL GAINS TO ORGAN TOLERANCE RESTRICTIONS [J].
LANGER, M ;
KIJEWSKI, P .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1992, 22 (02) :325-332
[7]   OPTIMIZATION OF BEAM WEIGHTS UNDER DOSE-VOLUME RESTRICTIONS [J].
LANGER, M ;
LEONG, J .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1987, 13 (08) :1255-1260
[8]   THE EFFECT ON MINIMUM TUMOR DOSE OF RESTRICTING TARGET-DOSE INHOMOGENEITY IN OPTIMIZED 3-DIMENSIONAL TREATMENT OF LUNG-CANCER [J].
LANGER, M ;
KIJEWSKI, P ;
BROWN, R ;
HA, C .
RADIOTHERAPY AND ONCOLOGY, 1991, 21 (04) :245-256
[9]   LARGE-SCALE OPTIMIZATION OF BEAM WEIGHTS UNDER DOSE-VOLUME RESTRICTIONS [J].
LANGER, M ;
BROWN, R ;
URIE, M ;
LEONG, J ;
STRACHER, M ;
SHAPIRO, J .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1990, 18 (04) :887-893
[10]  
MARSTEN RE, 1985, UNPUB USERS MANUAL Z