ANTIGENIC STREPTOCOCCAL COMPONENTS IN ACUTE GLOMERULONEPHRITIS

被引：63

作者：

TRESER, G

SEMAR, M

MCVICAR, M

FRANKLIN, M

TY, A

SAGEL, I

LANGE, K

机构：

[1] Renal Service and Laboratory, Departments of Medicine and Pediatric, New York Medical College, New York

来源：

SCIENCE | 1969年 / 163卷 / 3868期

关键词：

D O I：

10.1126/science.163.3868.676

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Fluorescein-labeled immunoglobulin G fractions from serums of patients with acute glomerulonephritis and from many normal serums stained the glomerular basement membrane and mesangium of renal tissue from patients with early acute glomerulonephritis; these serums did not stain the corresponding tissues from patients with any other kidney disease. Previous absorption of the serum fraction with frozen and thawed nephritogenic beta hemolytic streptococci abolished all staining. Other bacteria studied did not abolish the staining. Only the plasma membrane of the streptococcus absorbed the immunoglobulin G fraction; such absorption eliminated staining. Fluorescein-labeled antiserums against streptococcal plasma membrane had staining properties similar to patients' serums.

引用

页码：676 / &

共 11 条

[1] IMPROVED TECHNIQUE FOR PREPARATION OF STREPTOCOCCAL CELL WALLS [J].