STIMULATION OF COLLAGEN-SYNTHESIS IN FIBROBLAST-CULTURES BY A TRITERPENE EXTRACTED FROM CENTELLA-ASIATICA

被引：118

作者：

MAQUART, FX

BELLON, G

GILLERY, P

WEGROWSKI, Y

BOREL, JP

机构：

[1] Laboratory of Biochemistry, CNRS URA 610, Faculty of Medicine, 51095, Reims cedex

来源：

CONNECTIVE TISSUE RESEARCH | 1990年 / 24卷 / 02期

关键词：

Collagen synthesis; Fibroblast cultures; Triterpenes; Wound healing;

D O I：

10.3109/03008209009152427

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The drug "Titrated Extract from Centella asiatica" (TECA), used for its stimulating properties on the healing of wounds, is a mixture of 3 terpenes extracted from a tropical plant: asiatic acid (30% w/w), madecassic acid (30% w/w) and asiaticoside (40% w/w). The effects of TECA and its individual components were checked on human foreskin fibroblast monolayer cultures. TECA increased the collagen synthesis in a dose-dependent fashion whereas a simultaneous decrease in the specific activity of neosynthesized collagen was observed. Asiatic acid was found to be the only component responsible for collagen synthesis stimulation. TECA and all three terpenes increased the intracellular free proline pool. This effect was independent of the stimulation of collagen synthesis. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：107 / 120

页数：14

共 29 条

[1] EFFECTS OF PREFORMED PROLINE AND PROLINE AMINO-ACID PRECURSORS (INCLUDING GLUTAMINE) ON COLLAGEN-SYNTHESIS IN HUMAN FIBROBLAST-CULTURES [J].