PROTEOLYTIC-ENZYME ACTIVITY IN PATIENTS WITH SEVERE HEAD-INJURY AND THE EFFECT OF A PROTEINASE-INHIBITOR

被引：16

作者：

AUER, LM ^{[1
]}

MARTH, E ^{[1
]}

HEPPNER, F ^{[1
]}

HOLASEK, A ^{[1
]}

机构：

[1] INST MED BIOCHEM,GRAZ,AUSTRIA

来源：

ACTA NEUROCHIRURGICA | 1979年 / 49卷 / 3-4期

关键词：

CSF-proteases; Head injury; Protease inhibitor;

D O I：

10.1007/BF01808960

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A study was performed to detect the inhibitory effect of intravenously administered aprotinin (Trasylol®) on brain and CSF protease activity in 25 patients with severe head injury. The data presented include measurements of CSF protease activity, alpha-1-antitrypsin, alpha-2-macroglobulin, haptoglobulin, polyacrylamidgel-electrophoresis pattern, total protein and hemoglobin content. The results indicate that increased protease activity is present and that this induces autolytic processes which can be inhibited by aprotinin treatment. The survival rate was higher after aprotinin treatment. Total CSF protein content was significantly higher in nonsurvivors than in survivors. © 1979 Springer-Verlag.

引用

页码：207 / 217

页数：11

共 29 条

[1]

ARNDTS D, 1970, ARZNEI-FORSCHUNG, V20, P667

[2]

AUER L, 1975, WIEN KLIN WOCHENSCHR, V87, P556

[3] SERUM HAPTOGLOBULIN CHANGES IN PATIENTS WITH SEVERE ISOLATED HEAD-INJURY [J].