SYNTHESIS AND EVALUATION OF PARAMAGNETIC PARTICULATES AS CONTRAST AGENTS FOR MAGNETIC-RESONANCE-IMAGING (MRI)

被引：3

作者：

BRAYBROOK, JH ^{[1
]}

HALL, LD ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,SCH CLIN MED,HERCHEL SMITH LAB MED CHEM,CAMBRIDGE CB2 2PZ,ENGLAND

来源：

POLYMER INTERNATIONAL | 1991年 / 26卷 / 04期

关键词：

PARTICULATE; PARAMAGNETIC; CONTRAST AGENTS; NUCLEAR MAGNETIC RESONANCE IMAGING (NMR) (MRI);

D O I：

10.1002/pi.4990260409

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Formulations based on novel particulate ion-exchange resins, containing a wide range of paramagnetic transition and rare-earth metals bound to their surfaces, have been synthesised as potential contrast agents for the magnetic resonance imaging (MRI) of the gastro-intestinal (GI) tract of man. They have been evaluated in terms of their effects upon the spin-lattice (R1) and spin-spin (R2) relaxation rates of the protons of water. Careful selection of the polymer, spacer-arm, ligand and paramagnetic ion provides a means for subtle molecular tailoring. Further potential applications have been highlighted based on the observed properties of such formulations.

引用

页码：251 / 259

页数：9

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