COMPARATIVE SPECTROPHOTOMETRIC ANALYSIS OF RIFAMPICIN BY CHELATE FORMATION AND CHARGE-TRANSFER COMPLEXATION

被引：11

作者：

GALAL, SM

BLAIH, SM

ABDELHAMID, ME

机构：

[1] Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Alexandria

来源：

ANALYTICAL LETTERS | 1992年 / 25卷 / 04期

关键词：

RIFAMPICIN; CUPRIC ION; CHELATE; HALOGENATED QUINONES; CHARGE-TRANSFER COMPLEX; CAPSULES; AND URINE ANALYSIS;

D O I：

10.1080/00032719208020030

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Simple, rapid, and accurate spectrophotometric procedures for the determination of the antibiotic rifampicin, in capsules, are presented. A chelate formation of the antibiotic with cupric ion and charge-transfer complexation with halogenated quinones are carried out. Linear correlations between absorbance and concentration over the range of 40-100-mu-g ml-1 were computed. The reaction pathways were proposed. The utility of copper chelate as a stability indicating procedure as well as a method to determine rifampicin in spiked urine samples is demonstrated.

引用

页码：725 / 743

页数：19

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