CLONING, EXPRESSION AND LOCALIZATION OF AN RNA HELICASE GENE FROM A HUMAN LYMPHOID-CELL LINE WITH CHROMOSOMAL BREAKPOINT 11Q23.3

被引：67

作者：

DAN, L ^{[1
]}

YUNIS, JJ ^{[1
]}

机构：

[1] HAHNEMANN UNIV,DEPT NEOPLAST DIS,PHILADELPHIA,PA 19102

来源：

NUCLEIC ACIDS RESEARCH | 1992年 / 20卷 / 08期

关键词：

D O I：

10.1093/nar/20.8.1967

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A gene encoding a putative human RNA helicase, p54, has been cloned and mapped to the band q23.3 of chromosome 11. The predicted amino acid sequence shares a striking homology (75% identical) with the female germline-specific RNA helicase ME31B gene of Drosophila. Unlike ME31B, however, the new gene expresses an abundant transcript in a large number of adult tissues and its 5' non-coding region was found split in a t(11;14)(q23.3;q32.3) cell line from a diffuse large B-cell lymphoma.

引用

页码：1967 / 1972

页数：6

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