GROWTH-HORMONE TREATMENT DURING PREGNANCY IN A GROWTH HORMONE-DEFICIENT WOMAN

被引:18
作者
MULLER, J
STARUP, J
CHRISTIANSEN, JS
JORGENSEN, JOL
JUUL, A
SKAKKEBAEK, NE
机构
[1] RIGSHOSP, DEPT OBSTET & GYNAECOL, DK-2100 COPENHAGEN, DENMARK
[2] AARHUS UNIV HOSP, DEPT INTERNAL MED M, DK-8000 AARHUS, DENMARK
关键词
D O I
10.1530/eje.0.1320727
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Information on the course and outcome of pregnancies in growth hormone (GH)-deficient patients is sparse, and GH treatment during pregnancy in such women has not been described previously. We have studied fetal growth and serum levels of GH, insulin-like growth factor I (IGF-I) and IGF binding protein 3 (IGFBP-3) during pregnancy, as well as birth weight and hormone levels after delivery in a 25-year-old woman with idiopathic, isolated GH deficiency diagnosed at the age of 7 years. As part oi a clinical trial, the patient was treated with 2,IU/M(2) GH for a period of 5 years. At this time she became pregnant after donor insemination. The GH treatment was continued until variant GH production from the placenta was evident. Serum levels of GH, IGF-I and IGFBP-3 were measured monthly during pregnancy after 3 days off GH therapy, Abdominal ultrasound was performed five times, Hormonal levels were measured immediately after delivery and during the following days, Serum GH and IGF-I levels increased during the second half of pregnancy; serum IGFBP-3 remained constant throughout pregnancy at a normal level, Serum levels of GH fell within Ih after delivery, and levels of IGF-I and IGFBP-3 decreased into the range of GH-deficient women 4 days after. The fetal biparietal diameter increased normally, and birthweight was 3.564 kg, length 52 cm, No adverse events were recorded, We conclude that the role of GH replacement during pregnancy of GH-deficient women should be investigated further.
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页码:727 / 729
页数:3
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