HIGH-LEVELS OF HUMAN PERIPHERAL-BLOOD MONONUCLEAR CELL ENGRAFTMENT AND ENHANCED SUSCEPTIBILITY TO HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION IN NOD/LTSZ-SCID/SCID MICE

被引：127

作者：

HESSELTON, RM

GREINER, DL

MORDES, JP

RAJAN, TV

SULLIVAN, JL

SHULTZ, LD

机构：

[1] UNIV MASSACHUSETTS,SCH MED,DEPT MED,WORCESTER,MA 01605

[2] UNIV MASSACHUSETTS,SCH MED,PROGRAM MOLEC MED,WORCESTER,MA 01605

[3] UNIV CONNECTICUT,CTR HLTH,DEPT PATHOL,FARMINGTON,CT

[4] UNIV CONNECTICUT,CTR HLTH,DEPT MICROBIOL,FARMINGTON,CT

[5] JACKSON LAB,BAR HARBOR,ME

来源：

JOURNAL OF INFECTIOUS DISEASES | 1995年 / 172卷 / 04期

关键词：

D O I：

10.1093/infdis/172.4.974

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Inbred C.B-17-scid/scid mice accept human peripheral blood mononuclear cell (PBMC) xenografts and are susceptible to human immunodeficiency virus type 1 (HIV-1) infection, but low levels of PBMC engraftment impede use of this system in HIV research, This report describes the effect of host strain background on human PBMC engraftment and HIV infectivity in scid mice. Backcrossing the scid mutation to the NOD/Lt strain (designated NOD/LtSz-scid/scid) increased the percentage of engrafted human PBMC in recipient spleens by 5- to 10-fold compared with that in C.B-17-scid/scid stock. Four weeks after human PBMC-injected mice were infected with HIV-1, 79% of NOD/LtSz-scid/scid spleens harbored replicating virus compared with only 39% of spleens in C.B-17-scid/scid mice. The NOD/LtSz-scid/scid mouse may provide a useful small animal model for studies of HIV-1.

引用

收藏

页码：974 / 982

页数：9

相关论文

共 68 条

[41] MURINE ADENOVIRUS INFECTION OF SCID MICE INDUCES HEPATIC-LESIONS THAT RESEMBLE HUMAN REYE SYNDROME [J].

PIROFSKI, L ;

HORWITZ, MS ;

SCHARFF, MD ;

FACTOR, SM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (10) :4358-4362

[42] FAILURE OF A HUMAN IMMUNODEFICIENCY VIRUS (HIV) IMMUNE GLOBULIN TO PROTECT CHIMPANZEES AGAINST EXPERIMENTAL CHALLENGE WITH HIV [J].

PRINCE, AM ;

HOROWITZ, B ;

BAKER, L ;

SHULMAN, RW ;

RALPH, H ;

VALINSKY, J ;

CUNDELL, A ;

BROTMAN, B ;

BOEHLE, W ;

REY, F ;

PIET, M ;

REESINK, H ;

LELIE, N ;

TERSMETTE, M ;

MIEDEMA, F ;

BARBOSA, L ;

NEMO, G ;

NASTALA, CL ;

ALLAN, JS ;

LEE, DR ;

EICHBERG, JW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (18) :6944-6948

[43] PREVENTION OF HIV-INFECTION BY PASSIVE-IMMUNIZATION WITH HIV IMMUNOGLOBULIN [J].

PRINCE, AM ;

REESINK, H ;

PASCUAL, D ;

HOROWITZ, B ;

HEWLETT, I ;

MURTHY, KK ;

COBB, KE ;

EICHBERG, JW .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1991, 7 (12) :971-973

[44] SELECTIVE RECONSTITUTION OF LYMPHOCYTE-T SUBSETS IN SCID MICE [J].

REIMANN, J ;

RUDOLPHI, A ;

CLAESSON, MH .

IMMUNOLOGICAL REVIEWS, 1991, 124 :75-95

[45] HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION OF NEONATAL SEVERE COMBINED IMMUNODEFICIENT MICE XENOGRAFTED WITH HUMAN CORD-BLOOD CELLS [J].

REINHARDT, B ;

TORBETT, BE ;

GULIZIA, RJ ;

REINHARDT, PP ;

SPECTOR, SA ;

MOSIER, DE .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1994, 10 (02) :131-141

[46] HUMAN AUTOIMMUNE DIABETES-MELLITUS - LESSONS FROM BB RATS AND NOD MICE - CAVEAT-EMPTOR [J].

ROSSINI, AA ;

HANDLER, ES ;

MORDES, JP ;

GREINER, DL .

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1995, 74 (01) :2-9

[47] HU-PBL-SCID MICE CAN BE PROTECTED FROM HIV-1 INFECTION BY PASSIVE TRANSFER OF MONOCLONAL-ANTIBODY TO THE PRINCIPAL NEUTRALIZING DETERMINANT OF ENVELOPE GP120 [J].

SAFRIT, JT ;

FUNG, MSC ;

ANDREWS, CA ;

BRAUN, DG ;

SUN, WNC ;

CHANG, TW ;

KOUP, RA .

AIDS, 1993, 7 (01) :15-21

[48] PRIMER-DIRECTED ENZYMATIC AMPLIFICATION OF DNA WITH A THERMOSTABLE DNA-POLYMERASE [J].

SAIKI, RK ;

GELFAND, DH ;

STOFFEL, S ;

SCHARF, SJ ;

HIGUCHI, R ;

HORN, GT ;

MULLIS, KB ;

ERLICH, HA .

SCIENCE, 1988, 239 (4839) :487-491

[49]

SANDHU J, 1994, J IMMUNOL, V152, P3806

[50] LIMITED B-CELL REPERTOIRE IN SEVERE COMBINED IMMUNODEFICIENT MICE ENGRAFTED WITH PERIPHERAL-BLOOD MONONUCLEAR-CELLS DERIVED FROM IMMUNODEFICIENT OR NORMAL HUMANS [J].

SAXON, A ;

MACY, E ;

DENIS, K ;

TARYLEHMANN, M ;

WITTE, O ;

BRAUN, J .

JOURNAL OF CLINICAL INVESTIGATION, 1991, 87 (02) :658-665

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