PORTAL-VEIN EMBOLIZATION WITH ETHANOL INJECTION VIA A FINE-NEEDLE IN DOGS

被引:15
作者
LU, MD
LIANG, LJ
HUANG, JF
YE, WJ
YANG, QS
PENG, BG
XIE, XY
机构
[1] Department of Hepatobiliary Surgery, First Affiliated Hospital, Sun Yet-Sen University of Medical Sciences, Guangzhou, 510080, 58
来源
SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY | 1995年 / 25卷 / 05期
关键词
PORTAL VEIN; THERAPEUTIC EMBOLIZATION; ABSOLUTE ETHANOL; DOGS;
D O I
10.1007/BF00311818
中图分类号
R61 [外科手术学];
学科分类号
摘要
We devised a method for portal vein embolization with ethanol injection (PVEEI) via a fine needle. Both the efficacy and safety of this procedure were evaluated in 28 dogs. An embolization of the left central and lateral lobes was undertaken with various doses of absolute (95%) ethanol. The smallest dose, 0.25 ml/kg ethanol (n = 7), caused the least damage to the liver, but the embolization was not complete. At the highest dose at 1.0 ml/kg, four of the seven dogs died of respiratory arrest; however, embolization was complete in the remaining dogs. All animals tolerated the procedure by 0.5 ml/kg ethanol (n = 11) with a satisfactory embolic effect, slight toxicity to the hepatic parenchyma, and only transient changes in liver function. The results suggested that PVEEI is safe and effective when a suitable dose of ethanol is administered. Local overembolization occurred in one dog due to extension of the thrombus, suggesting that the point of puncture should not be near the confluence of the branches. Since a selective portal venous puncture is not difficult to perform under sonographic guidance, PVEEI is expected to be clinically applied.
引用
收藏
页码:416 / 420
页数:5
相关论文
共 13 条
[1]  
Liang L.J., Ye W.J., Lu M.D., Zhen Y.Y., Ye X.M., Cao X.F., Hepatic arterial chemoembolization in patients with huge sized liver cancer, Chin J Dig, 11, pp. 216-218, (1991)
[2]  
Yamashita Y., Takahashi M., Koga Y., Saito R., Nanakawa S., Hatanaka Y., Sato N., Nakashima K., Urata J., Yoshizumi K., Ito K., Sumi S., Kan M., Prognostic factors in the treatment of hepatocellular carcinoma with transcatheter arterial embolization and arterial infusion, Cancer, 67, pp. 385-391, (1991)
[3]  
Liang L.J., Lu M.D., Ye W.J., Huang J.F., Two-stage resection for advanced hepatocellular carcinoma, Chung Hua Chung Liu Tsa Chih (Chin J Oncol), 14, pp. 449-451, (1992)
[4]  
Kinoshita H., Sakai K., Hirohashi K., Igawa S., Yamasaki O., Kubo S., Preoperative portal vein embolization for hepatocellular carcinoma, World J Surg, 10, pp. 803-808, (1986)
[5]  
Monden M., Okamura J., Sakon M., Gotoh M., Kobayashi K., Umeshita K., Yamada T., Kuroda C., Sakurai M., Mori T., Significance of transcatheter chemoembolization combined with surgical resection for hepatocellular carcinomas, Cancer Chemother Pharmacol, 23, pp. 590-595, (1989)
[6]  
Honjo I., Suzuki T., Ozawa K., Takasan H., Kitamura O., Ishikawa T., Ligation of a branch of the portal vein for carcinoma of the liver, Am J Surg, 130, pp. 296-302, (1975)
[7]  
Matsumata T., Kanematsu T., Takenaka K., Sugimachi K., Lack of intrahepatic recurrence of hepatocellular carcinoma by temporary portal venous embolization with starch microspheres, Surgery, 105, pp. 188-191, (1989)
[8]  
Nakao N., Miura K., Takahashi H., Ohnishi M., Miura T., Okamato E., Ishikawa Y., Hepatocellular carcinoma: combined hepatic, arterial, and portal venous embolization, Radiology, 161, pp. 303-307, (1986)
[9]  
Pan C.E., Sequential hepatic artery and portal vein embolization using lipiodol-adriamycin for primary liver cancer, Chung Hua Chung Liu Tsa Chih (Chin J Oncol), 13, pp. 372-374, (1991)
[10]  
Fujio N., Sakai K., Kinoshita H., Hirohashi K., Kubo S., Iwasa R., Lee K.C., Results of treatment of patients with hepatocellular carcinoma with severe cirrhosis of the liver, World J Surg, 13, pp. 211-218, (1989)