A series of Me substituted perhydropyrido [1,2-c]pyrrolo [2,1-e] imidazoles have been synthesized and their configurations and preferred conformations assigned on the basis of the 2800-2700 cm-1 region of their IR spectra and from a study of their PMR spectra with particular reference to the geminal coupling constant of the C6 methylene protons. The influence of dipole interactions in determining conformational preferences in these compounds is discussed. © 1969.