SMALL INCREASES IN CIRCULATING LUTEINIZING-HORMONE (LH) CONCENTRATIONS SHORTLY BEFORE HUMAN CHORIONIC-GONADOTROPIN (HCG) ARE ASSOCIATED WITH REDUCED INVITRO FERTILIZATION (IVF) PREGNANCY RATE

被引：10

作者：

MUNABI, AK

KING, D

BENDER, S

BUSTILLO, M

DORFMANN, A

SCHULMAN, JD

机构：

[1] Genetics and IVF Institute, Fairfax, 22031, Virginia

[2] The Medical College of Virginia, Richmond, 23298, Virginia

来源：

JOURNAL OF IN VITRO FERTILIZATION AND EMBRYO TRANSFER | 1990年 / 7卷 / 06期

关键词：

in vitro fertilization; luteinizing hormone rise; pregnancy rate;

D O I：

10.1007/BF01130581

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The effects of slight elevations in serum LH just before hCG administration on IVF cycle outcome were studied in 219 women undergoing retrieval. One hundred seven patients were stimulated using human menopausal gonadotropin (hMG), and 112 received clomiphene citrate and hMG. Serum LH, estradiol (E2), and progesterone concentrations were measured before and during controlled ovarian stimulation. Retrospectively the women were subdivided into three groups based on serum LH before hCG: Group I, <50% LH rise from baseline (BL) value (mean of day 2 and day 7); Group II, LH rise ≥50% but <2×BL; and, Group III, LH rise ≥2×BL. The fertilization and cleavage rates were similar in all groups. However, a ≥50% rise in serum LH before hCG was associated with a significantly reduced IVF pregnancy rate. © 1990 Plenum Publishing Corporation.

引用

页码：310 / 313

页数：4

共 10 条

[1]

Glasier A., Thatcher S.S., Wickings E.J., Hillier S.G., Baird D.T., Superovulation with exogenous gonadotropins does not inhibit the luteinizing hormone surge, Fertil Steril, 49, (1988)

[2]

Huang K., Chang S.Y., Muechler E.K., Graham M.C., The outcome of continued treatment of luteinizing hormone-surge cycles in in vitro fertilization with the use of human menopausal gonadotropins, Fertil Steril, 47, (1987)

[3]

Eibschitz I., Belaisch-Allait J.C., Frydman R., In vitro fertilization management and results in stimulated cycles with spontaneous luteinizing hormone discharge, Fertil Steril, 45, (1986)

[4]

Wang T.A., Armant D.R., Taymor M.L., Seibel M.M., The influence of exogenous human chorionic gonadotropin cycles with spontaneous luteinizing hormone surges on the outcome of in vitro fertilization, Fertil Steril, 48, (1987)

[5]

Droesch K., Muasher S.J., Kreiner D., Jones G.S., Acosta A.A., Rosenwaks Z., Timing of oocyte retrieval in cycles with a spontaneous luteinizing hormone surge in a large in vitro fertilization program, Fertil Steril, 50, (1988)

[6]

Talbert L.M., Endogenous luteinizing hormone surge and superovulation, Fertil Steril, 49, (1988)

[7]

Nader S., Berkowitz A.S., Ochs D., Wolf D.P., Maklad N., Held B., Patterns of estradiol responses in patients with endogenous gonadotropin surges during follicular recruitment in an in vitro fertilization and embryo transfer program, Fetil Steril, 46, (1986)

[8]

Schulman J.D., Dorfmann A.D., Jones S.L., Pitt C.C., Joyce B., Patton L.A., Outpatient in vitro fertilization using transvaginal ultrasound guided oocyte retrieval, Obstet Gynecol, 69, (1987)

[9]

Vargyas J.M., Morente C., Shangold G., Marrs R.P., The effect of different methods of ovarian stimulation for human in vitro fertilization and embryo replacement, Fertil Steril, 42, (1984)

[10]

Lejeune B., Degueldre M., Camus M., Velcemans M., Opsomer L., LeRoy F., In vitro fertilization and embryo transfer as related to endogenous luteinizing hormone rise or human chorionic gonadotropin administration, Fertil Steril, 45, (1986)

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