MIRROR POLYDACTYLY - PATHOGENESIS BASED ON A MORPHOGEN GRADIENT THEORY

被引：29

作者：

VILJOEN, DL

KIDSON, SH

机构：

[1] UNIV CAPE TOWN, DEPT ANAT, CAPE TOWN 7925, SOUTH AFRICA

[2] UNIV CAPE TOWN, DEPT CELL BIOL, CAPE TOWN 7925, SOUTH AFRICA

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS | 1990年 / 35卷 / 02期

关键词：

Calcaneal duplication; Fibular duplication; Limb malformation; Morphogen gradient hypothesis; Sacrococcygeal teratoma; Tibial aplasia;

D O I：

10.1002/ajmg.1320350217

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We report on an infant with 7 toes of the left foot in a mirror configuration in association with ipsilateral duplication of the calcaneus and fibula, tibial aplasia, femoral hypoplasia, and a teratomatous sacrococcygeal tumour. The possible pathogenetic mechanisms leading to this limb abnormality are discussed with special emphasis on a field morphogen gradient hypothesis.

引用

页码：229 / 235

页数：7

共 22 条

[1] VIEWS OF LIMB DEVELOPMENT AND REGENERATION
BRYANT, SV
MUNEOKA, K
[J]. TRENDS IN GENETICS, 1986, 2 (06) : 153 - 159
[2] EXPERIMENTAL-ANALYSIS OF ORIGIN OF WING MUSCULATURE IN AVIAN EMBRYOS
CHRIST, B
JACOB, HJ
JACOB, M
[J]. ANATOMY AND EMBRYOLOGY, 1977, 150 (02): : 171 - 186
[3] ACROCEPHALOPOLYSYNDACTYLY TYPE-II - CARPENTER SYNDROME - CLINICAL SPECTRUM AND AN ATTEMPT AT UNIFICATION WITH GOODMAN AND SUMMIT SYNDROMES
COHEN, DM
GREEN, JG
MILLER, J
GORLIN, RJ
REED, JA
[J]. AMERICAN JOURNAL OF MEDICAL GENETICS, 1987, 28 (02): : 311 - 324
[4] MYOGENIC AND CHONDROGENIC LINEAGES IN DEVELOPING LIMB BUDS GROWN INVITRO
DIENSTMAN, SR
BIEHL, J
HOLTZER, S
HOLTZER, H
[J]. DEVELOPMENTAL BIOLOGY, 1974, 39 (01) : 83 - 95
[5] UNUSUAL DYSPLASIA-MALFORMATION-CANCER SYNDROME IN 2 PATIENTS
DURKINSTAMM, MV
GILBERT, EF
GANICK, DJ
OPITZ, JM
[J]. AMERICAN JOURNAL OF MEDICAL GENETICS, 1978, 1 (03): : 279 - 289
[6] GOETINCK PF, 1966, CURRENT TOPICS DEVEL, P253
[7] HORNBRUCH A, 1986, J EMBRYOL EXP MORPH, V94, P257
[8] LUBINSKY M, 1987, DYSMORPHOL CLIN GENE, V1, P21
[9] MOORE KL, 1988, DEV HUMAN
[10] Rudnick D., 1945, Transactions of the Connecticut Academy of Arts and Science, V36, P353

← 1 2 3 →