PERMANGANATE OXIDATION OF ERGOSTEROL

被引：13

作者：

ANASTASIA, M

FIECCHI, A

SCALA, A

机构：

[1] Institute of Chemistry, School of Medicine, University of Milan, Milano

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1979年 / 44卷 / 21期

关键词：

D O I：

10.1021/jo01335a008

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The oxidation of ergosterol in methylcyclohexane with aqueous permanganate affords 3β,5α,6α-trihydroxyergosta-7,22-diene, 7α,8α-epoxy-5α-ergost-22-ene-3β,5,6α-triol (major component), 3β,5α,6α,7α-tetrahydroxyergosta-8(14),22-diene, and 3β,5α,6α,7a-tetrahydroxyergosta-8(9),22-diene. The product obtained by M. Fieser et al. and identified as 3β,5α,6α-trihydroxyergosta-7,14,22-triene has been demonstrated to be constituted mainly of 3β,5α,6α-trihydroxyergosta-7,9(ll),22-triene and 3β,5α,6α-trihydroxyergosta-7,22-diene, with 3β,5α,6α-trihydroxyergosta-7,14,22-triene as a minor component. The trienic compounds were formed during the isolation procedure used by the authors. © 1979, American Chemical Society. All rights reserved.

引用

页码：3657 / 3661

页数：5

共 14 条

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