IMMUNOLOGICAL INSITU IDENTIFICATION OF THE LYMPHOID-CELLS IN THE SKIN INFILTRATE OF LICHEN PLANUS

被引:35
作者
BRAATHEN, LR
DAL, BL
MELLBYE, OJ
机构
[1] Department of Dermatology, Institute of Immunology and Rheumatology, Rikshospitalet, University Hospitals, Oslo
关键词
D O I
10.1111/j.1365-2230.1979.tb01615.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
A specific rabbit anti‐human T‐lymphocyte antiserum has been used in an indirect immunofluorescence technique to identify T lymphocytes in situ in tissue sections from lichen planus skin lesions. T lymphocytes were also identifiedin situ by means of aminoethylisothiouronium bromide‐treated sheep red blood cells, using an immune adherence technique. Various types of coated sheep red blood cells were utilized to detect cells with receptors for FcIgG and complement factor C3b. The results demonstrated the presence of predominantly T lymphocytes, and probably some macrophages and few B lymphocytes in the skin infiltrate of lichen planus. Total and differential white count as well as relative and absolute numbers of B and T lymphocytes in peripheral blood were also determined, and found to be within the normal range. Copyright © 1979, Wiley Blackwell. All rights reserved
引用
收藏
页码:175 / 185
页数:11
相关论文
共 27 条
  • [1] Baart de la Faille-Kuyper E.H., Baart de la Faille H., An immunofluorescence study of lichen planus, British Journal of Dermatology, 90, pp. 365-371, (1974)
  • [2] Bankhurst A.D., Husby G., Williams R.C., Predominance of T cells in the lymphocytic infiltrates of synovial tissues in rheumatoid arthritis, Arthritis and Rheumatism, 19, pp. 555-562, (1976)
  • [3] Beckett R.C., Bankhurst A.D., Van Epps D.E., Williams R.C., Empiric analysis of the interactions involved in the formation of Fc receptor rosettes, International Archives of Allergy and Applied Immunology, 56, pp. 65-72, (1978)
  • [4] Bjerke J.R., Keogh H.K., (1977)
  • [5] Black M.M., What is going on in lichen planus?, Clinical and Experimental Dermatology, 2, pp. 303-310, (1977)
  • [6] Boyum A., Isolation of lymphocytes, granulocytes and macrophages, Scandinavian Journal of Immunology, 5, (1976)
  • [7] Ebner H., Untersuchungen über die celluläte Zusammensetzung des lichen ruber planus infiltrates, Archiv für Dermatologische Forschung, 247, pp. 309-318, (1973)
  • [8] Edelson R.L., Smith R.W., Frank M.M., Green I., Identification of subpopulations of mononuclear cells in cutaneous infiltrates. I. Differentiation between B cells, T cells and histiocytes, Journal, of Investigative Dermatology, 61, pp. 82-89, (1973)
  • [9] Froland S.S., Natvig J.B., Class, subclass and allelic exclusion of membrane bound Ig of human lymphocytes, Journal of Experimental Medicine, 136, pp. 409-414, (1972)
  • [10] Fryand O., Mellbye O.J., Natvig J.B., Immunofluorescence studies for immunoglobulins and complement C<sub>3</sub> in synovial joint membranes in psoriatic arthritis, Clinical and Experimental Immunology, 29, pp. 422-427, (1977)