ASBESTOS-ASSOCIATED NEOPLASMS OF B-CELL LINEAGE

被引：54

作者：

KAGAN, E

JACOBSON, RJ

YEUNG, KY

HAIDAK, DJ

NACHNANI, GH

机构：

[1] GEORGETOWN UNIV,SCH MED,DEPT MED,DIV ONCOL,WASHINGTON,DC 20007

[2] GEORGETOWN UNIV,MED CTR,DEPT MED,DIV HEMATOL & ONCOL,WASHINGTON,DC 20007

[3] SO MARYLAND HOSP,DEPT INTERNAL MED,CLINTON,MD

来源：

AMERICAN JOURNAL OF MEDICINE | 1979年 / 67卷 / 02期

关键词：

D O I：

10.1016/0002-9343(79)90408-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Three different neoplasms of B cell lineage, chronic lymphocytic leukemia, immunoglobulin A (IgA) myeloma and immunoglobulin G (IgG) myeloma were detected in three patients who had heavy occupational exposure to asbestos dust. Two of the patients had coexistent pulmonary asbestosis, whereas the third patient had a pleural mesothelioma subsequent to his initial presentation with myeloma. Defective cell-mediated immunity and hyperactivity of B cell function have previously been noted in patients with asbestosis. We suggest the possibility that these asbestos-related immunologic derangements may predispose to the development of immunoproliferative and lymphoproliferative neoplasms, since such tumors have been observed in a variety of other settings, characterized by protracted hyperactivity of the immune system. © 1979.

引用

页码：325 / 330

页数：6

共 27 条

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