7 PATIENTS WITH PLASMA-CELL GRANULOMA (INFLAMMATORY PSEUDOTUMOR) OF THE LUNG, INCLUDING 2 WITH INTRABRONCHIAL GROWTH - AN IMMUNOHISTOCHEMICAL AND ELECTRON-MICROSCOPIC STUDY

被引：21

作者：

NONOMURA, A

MIZUKAMI, Y

MATSUBARA, F

SHIMIZU, J

ODA, M

WATANABE, Y

KAMIMURA, R

TAKASHIMA, T

KITAGAWA, M

机构：

[1] Radiology, Kanazawa University Hospital, School of Medicine, Kanazawa University, Kanazawa

[2] Department of Pathology, Toyama Medical and Pharmaccutical University, Faculty of Medicine, Toyama

来源：

INTERNAL MEDICINE | 1992年 / 31卷 / 06期

关键词：

LUNG TUMOR; INFLAMMATION; PULMONARY INFECTION; IMMUNOHISTOCHEMISTRY; HISTIOCYTOMA; PLASMACYTOMA;

D O I：

10.2169/internalmedicine.31.756

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Seven patients (mean age, 50.7 +/- 20.4 years; range 21-77) with plasma cell granuloma (PCG) of the lung are reported. Cough and sputum were the most common presenting symptoms, followed by fever. Elevated erythrocyte sedimentation rate and serum C-reactive protein levels were found in all patients tested. Radiologically, five cases presented as solitary, well-circumscribed masses and two as ill-defined, pneumonia-like densities. One showed focal calcification. No predilection of occurrence was observed in either lobe of the lung. Histologically, the lesions consisted of a proliferation of mature plasma cells and reticulo-endothelial cells supported by a stroma of granulation tissue, with varying degrees of myxoid change or collagenization. Angioinvasion within the lesion was observed in 4 of the 7 cases. Immunohistochemical staining revealed the IgG-predominant polyclonal nature of the plasma cells, indicating a reactive inflammatory process rather than a neoplastic one. Electron microscopy confirmed the benign nature of the plasma cells with fibroblast and myofibroblast proliferation admixed with that of other inflammatory cells.

引用

页码：756 / 765

页数：10

共 17 条

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