AN EVALUATION OF SELF-MEASURED BLOOD-PRESSURE IN A STUDY WITH A CALCIUM-CHANNEL ANTAGONIST VERSUS A BETA-BLOCKER

被引：35

作者：

MENGDEN, T ^{[1
]}

BINSWANGER, B ^{[1
]}

WEISSER, B ^{[1
]}

VETTER, W ^{[1
]}

机构：

[1] UNIV HOSP ZURICH,DEPT INTERNAL MED,RAEMISTR 100,CH-8091 ZURICH,SWITZERLAND

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1992年 / 5卷 / 03期

关键词：

CASUAL BLOOD PRESSURE; AMBULATORY BLOOD PRESSURE; SELF-MEASURED BLOOD PRESSURE; BISOPROLOL; NITRENDIPINE;

D O I：

10.1093/ajh/5.3.154

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

In recent years self-measurement of blood pressure at home has gained increasing importance but there have been only a few studies comparing casual, ambulatory, and self-measured blood pressure determinations during a single clinical trial. We therefore compared treatment-induced blood pressure-reductions in a double-blind, placebo-controlled, parallel study design with a single morning dose of either 10 mg bisoprolol (n = 26) or 20 mg nitrendipine (n = 27) with casual blood pressure readings in the morning before the dose, ambulatory 24-h monitoring, and self-recorded measurements in the morning before the dose and in the evening. Mean reductions for systolic and diastolic blood pressure after 4 weeks of therapy were significantly greater for bisoprolol than for nitrendipine. The treatment-induced blood pressure reductions were most pronounced as assessed by casual readings but showed good agreement between casual, ambulatory, and self-measured blood pressure for group comparisons. In some patients, however, marked individual differences between the three methods were observed. Correlation coefficients between ambulatory and self-measured blood pressure were 0.4 for systolic blood pressure (P < .05) and 0.6 for diastolic blood pressure (P < .0005). Under the conditions of this parallel study design and the usual statistical risks, a difference of 5 mm Hg in diastolic blood pressure can be detected in 118 patients at the clinic, in 70 patients if ambulatory blood pressure is used, or in 56 patients if self-measured blood pressure is used. In conclusion, bisoprolol was more effective over 24 h than nitrendipine at the doses studied. Furthermore, self-measured blood pressure was suitable for monitoring 24-h efficacy of the two antihypertensive drugs under investigation. Finally, self-measured blood pressure can substantially improve the sensitivity of hypertension trials in comparison to casual readings and therefore reduce the number of patients included.

引用

页码：154 / 160

页数：7

共 25 条

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