DELTA-AMINOLEVULINIC-ACID DEHYDRATASE INACTIVATION BY UROPORPHYRIN-I IN LIGHT AND DARKNESS

被引：8

作者：

AFONSO, SG

CHINARRO, S

DESALAMANCA, RE

BATLLE, AMD

机构：

[1] UNIV BUENOS AIRES,CTR INVEST PORFIRINAS & PORFIRIAS,BUENOS AIRES,DF,ARGENTINA

[2] HOSP UNIV DOCE OCTOBRE,UNIDAD INVEST PORFIRIAS,MADRID,SPAIN

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1994年 / 26卷 / 02期

关键词：

D O I：

10.1016/0020-711X(94)90153-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. The action of uroporphyrin I on erythrocytic ALA-D activity under dark and light conditions was examined. 2. Photo and non-photoinactivation of ALA-D induced by uroporphyrin I were observed. 3. Both effects were dependent on uroporphyrin concentration, temperature and time of exposure of the protein to the porphyrin. 4. Light-dependent effect of uroporphyrin I is related with the phototoxicity of porphyrins and could be produced by primary amino acid photooxidation followed by secondary cross-linking of the protein. 5. Light-dependent effect of uroporphyrin I could be ascribed to a direct enzyme inhibition due to binding of the porphyrin to the protein inducing structural changes at or near its active site.

引用

页码：255 / 258

页数：4

共 30 条

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