DOES ENDOTOXIN STIMULATE CELLS BY MIMICKING CERAMIDE

被引：94

作者：

WRIGHT, SD ^{[1
]}

KOLESNICK, RN ^{[1
]}

机构：

[1] MEM SLOAN KETTERING CANC CTR,SIGNAL TRANSDUCT LAB,NEW YORK,NY 10021

来源：

IMMUNOLOGY TODAY | 1995年 / 16卷 / 06期

关键词：

D O I：

10.1016/0167-5699(95)80185-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent studies indicate that tumor necrosis factor (TNF) and interleukin 1 (IL-1) stimulate cells via the intracellular messenger ceramide. Bacterial endotoxin (lipopolysaccharide; LPS) shows strong structural and functional resemblance to ceramide. Here, Samuel Wright and Richard Kolesnick review data suggesting that LPS may provoke cellular responses by mimicking the action of ceramide.

引用

页码：297 / 302

页数：6

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