PREPARATION, RESOLUTION AND ABSOLUTE-CONFIGURATION OF 2,2'-BIPYRIDINE-3,3'-DICARBOXYLIC ACID 1,1'-DIOXIDE AND ITS ESTER

被引：24

作者：

TICHY, M ^{[1
]}

ZAVADA, J ^{[1
]}

PODLAHA, J ^{[1
]}

VOJTISEK, P ^{[1
]}

机构：

[1] CHARLES UNIV,DEPT INORGAN CHEM,CR-12840 PRAGUE 2,CZECH REPUBLIC

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 06期

关键词：

D O I：

10.1016/0957-4166(95)00160-Q

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The title racemic acid (+/-)-1, prepared by hydrogen peroxide oxidation of 2,2'-bipyridine-3,3'-dicarboxylic acid, was resolved via the brucine salts. The absolute configuration of acid (+)-1 was determined by X-ray diffraction study of its barium salt using the Bijvoet's anomalous dispersion method. The activation energy Delta G not equal for interconversion of enantiomers of the dimethyl ester 2 was found to be -106.5 kJ/mol at 50 degrees C.

引用

页码：1279 / 1282

页数：4

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