EFFECT OF DIAZOXIDE ON CORONARY BLOOD FLOW

Hemodynamic measurements were made on anesthetized and unanesthetized dogs to observe the effects of injection of diazoxide. The measurements included the electrocardiogram, blood pressures, cardiac output and coronary blood flow. Calculated values included coronary and total peripheral resistance, left ventricular work and efficiency. Coronary flow increased markedly and with larger doses the increase persisted for three to four hours. Calculated coronary arteriolar resistance decreased more in response to the diazoxide than did total peripheral resistance. Direct intracoronary injection of diazoxide in the conscious dog showed that the primary cardiac effect of this drug is to dilate the coronary arteriole. © 1969.