FORMAL TOTAL SYNTHESIS OF (-)-INDOLMYCIN

被引：42

作者：

AKITA, H

KAWAGUCHI, T

ENOKI, Y

OISHI, T

机构：

[1] Riken Institute (The Institute of Physical And Chemical Research), Saitama 351-01, 2-1 Hirosawa, Wako-sh

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1990年 / 38卷 / 02期

关键词：

(+)-indolmycenic ester; (-)-indolmycin; a-acetoxy ester; asymmetric hydrolysis; epoxide-ring opening; lipase;

D O I：

10.1248/cpb.38.323

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

(+)-Indolmycenic ester 4, a key intermediate for the synthesis of (-)-indolmycin (1), was prepared from (2S,3R)-epoxybutyrate 5 via (2S,3S)-2-hydroxy-3-chlorobutyrate 6 or (2R,3R)-2-mesyloxy-3-hydroxybutyrate 12, which were obtained by lipase-catalyzed kinetic resolution of the corresponding 2-acetates. © 1990, The Pharmaceutical Society of Japan. All rights reserved.

引用

页码：323 / 328

页数：6

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