ANTIRETROVIRAL ACTIVITY OF SYNTHETIC HYPERICIN AND RELATED ANALOGS

被引：59

作者：

KRAUS, GA ^{[1
]}

PRATT, D ^{[1
]}

TOSSBERG, J ^{[1
]}

CARPENTER, S ^{[1
]}

机构：

[1] IOWA STATE UNIV SCI & TECHNOL,DEPT VET MICROBIOL & PREVENT MED,AMES,IA 50011

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 172卷 / 01期

关键词：

D O I：

10.1016/S0006-291X(05)80185-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hypericin and pseudohypericin are naturally occurring polycyclic quinones which have recently been shown to inhibit the infectivity of several retroviruses, including human immunodeficiency virus. To better understand the antiviral mechanisms of these compounds, hypericin and a series of analogous quinones were synthesized and tested for anti-retroviral activity against equine infectious anemia virus (EIAV). Treatment of EIAV-infected cells with hypericin reduced the production of infectious virus by 99.99%. None of the analogs were found to inhibit virus replication. These results suggest that the complete ring structure of hypericin is required, but not sufficient, for antiviral activity. © 1990 Academic Press, Inc.

引用

页码：149 / 153

页数：5

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