TRICYCLIC ANTI-DEPRESSANTS AND IMIDAZOLINES AS INHIBITORS OF THE ALPHA-ADRENERGIC RECEPTOR MEDIATED STIMULATION OF PHOSPHATIDYLINOSITOL TURNOVER IN RAT PINEAL-GLAND

被引：10

作者：

SMITH, TL

HAUSER, G

机构：

[1] MCLEAN HOSP, RALPH LOWELL LABS, BELMONT, MA 02178 USA

[2] HARVARD UNIV, SCH MED, DEPT BIOL CHEM, BOSTON, MA 02115 USA

来源：

BIOCHEMICAL PHARMACOLOGY | 1979年 / 28卷 / 11期

关键词：

D O I：

10.1016/0006-2952(79)90537-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In intact rat pineal glands in vitro, norepinephrine stimulates the incorporation of 32P into phosphatidylinositol through post-synaptic alpha-adrenergic receptors. This response is inhibited by tricyclic antidepressants and imidazolines. Both amitriptyline and oxymetazoline displace the dose-response curve for norepinephrine to the right in a parallel manner indicative of a competitive mode of inhibition by these two classes of drugs. © 1979.

引用

页码：1759 / 1763

页数：5

共 28 条

[1] ROLE OF PHOSPHOLIPIDS IN MUSCARINIC BINDING BY NEURAL MEMBRANES
ARONSTAM, RS
ABOOD, LG
BAUMGOLD, J
[J]. BIOCHEMICAL PHARMACOLOGY, 1977, 26 (18) : 1689 - 1695
[2] DAVIS JN, 1978, J PHARMACOL EXP THER, V207, P425
[3] INDUCTION AND SUPERINDUCTION OF SEROTONIN N-ACETYLTRANSFERASE BY ADRENERGIC DRUGS AND DENERVATION IN RAT PINEAL ORGAN
DEGUCHI, T
AXELROD, J
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1972, 69 (08) : 2208 - &
[4] EICHBERG J, 1973, J BIOL CHEM, V248, P3615
[5] STIMULATION BY LOCAL-ANESTHETICS OF METABOLISM OF ACIDIC PHOSPHOLIPIDS IN RAT PINEAL-GLAND
EICHBERG, J
HAUSER, G
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1974, 60 (04) : 1460 - 1467
[6] EICHBERG J, 1973, Biochemical Society Transactions, V1, P352
[7] CARDIOVASCULAR EFFECTS OF AMITRIPTYLINE, NORTRIPTYLINE, PROTRIPTYLINE AND DOXEPIN IN CONSCIOUS RABBITS
ELONEN, E
MATTILA, MJ
SAARNIVAARA, L
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1974, 28 (01) : 178 - 188
[8] FOLCH J, 1957, J BIOL CHEM, V226, P497
[9] RELATIONSHIP OF ALPHA-ADRENERGIC RECEPTORS IN RAT PINEAL-GLAND TO DRUG-INDUCED STIMULATION OF PHOSPHOLIPID-METABOLISM
HAUSER, G
SHEIN, HM
EICHBERG, J
[J]. NATURE, 1974, 252 (5483) : 482 - 483
[10] HAUSER G, 1978, CYCLITOLS PHOSPHOINO, P167

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