ENANTIOMERIC SEPARATION OF SUBSTITUTED QUINUCLIDINES AND AZA-NORBORNANES BY HPLC USING AN ACETYLATED BETA-CYCLODEXTRIN BONDED STATIONARY PHASE

被引：4

作者：

BARNABY, RJ ^{[1
]}

MACLEOD, AM ^{[1
]}

机构：

[1] MERCK SHARP & DOHME LTD,NEUROSCI RES CTR,DEPT MED CHEM,HARLOW CM20 2QR,ESSEX,ENGLAND

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1991年 / 14卷 / 02期

关键词：

D O I：

10.1080/01483919108049615

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A method for the HPLC enantiomeric separation of substituted azabicycles (quinuclidines and aza-norbornanes) has been developed, after borane complexation with borane-THF, using an acetylated beta-cyclodextrin column. The procedure is relatively simple and has been applied to the determination of the enantiomeric purity of several synthetic compounds of potential pharmaceutical interest.

引用

页码：287 / 295

页数：9

共 10 条

[1] ABOULENEIN HY, 1988, J LIQ CHROMATOGR, V11, P1483
[2] POLAR-LIQUID, DERIVATIZED CYCLODEXTRIN STATIONARY PHASES FOR THE CAPILLARY GAS-CHROMATOGRAPHY SEPARATION OF ENANTIOMERS
ARMSTRONG, DW
LI, WY
CHANG, CD
PITHA, J
[J]. ANALYTICAL CHEMISTRY, 1990, 62 (09) : 914 - 923
[3] COMPARISON OF 2 BETA-CYCLODEXTRIN BONDED STATIONARY PHASES FOR HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY - ELUTION ORDER AND OPTICAL PURITY OF ENANTIOMERS OF CYCLOHEXYLPHENYLGLYCOLIC ACID
FEITSMA, KG
DRENTH, BFH
DEZEEUW, RA
[J]. JOURNAL OF CHROMATOGRAPHY, 1987, 387 : 447 - 452
[4] STRUCTURAL FACTORS AFFECTING CHIRAL RECOGNITION AND SEPARATION ON BETA-CYCLODEXTRIN BONDED PHASES
HAN, SM
HAN, YI
ARMSTRONG, DW
[J]. JOURNAL OF CHROMATOGRAPHY, 1988, 441 (02): : 376 - 381
[5] LIQUID-CHROMATOGRAPHIC SEPARATION OF ENANTIOMERS USING A CHIRAL BETA-CYCLODEXTRIN-BONDED STATIONARY PHASE AND CONVENTIONAL AQUEOUS ORGANIC MOBILE PHASES
HINZE, WL
RIEHL, TE
ARMSTRONG, DW
DEMOND, W
ALAK, A
WARD, T
[J]. ANALYTICAL CHEMISTRY, 1985, 57 (01) : 237 - 242
[6] MACCAUDIERE P, 1987, J CHROMATOGR, V405, P135
[7] SOME STRUCTURAL REQUIREMENTS FOR RESOLUTION OF HYDANTOIN ENANTIOMERS WITH A BETA-CYCLODEXTRIN LIQUID-CHROMATOGRAPHY COLUMN
MAGUIRE, JH
[J]. JOURNAL OF CHROMATOGRAPHY, 1987, 387 : 453 - 458
[8] STOTTER PL, 1987, HETEROCYCLES, V25, P251
[9] LIQUID-CHROMATOGRAPHIC SEPARATION OF RACEMATES ON ACETYLATED OR CARBAMOYLATED BETA-CYCLODEXTRIN-BONDED STATIONARY PHASES
TANAKA, M
SHONO, T
ZHU, DQ
KAWAGUCHI, Y
[J]. JOURNAL OF CHROMATOGRAPHY, 1989, 469 : 429 - 433
[10] IMPROVED CYCLODEXTRIN CHIRAL PHASES - A COMPARISON AND REVIEW
WARD, TJ
ARMSTRONG, DW
[J]. JOURNAL OF LIQUID CHROMATOGRAPHY, 1986, 9 (2-3): : 407 - 423

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