DIFFERENTIAL EXPRESSION OF A NOVEL MURINE NONRECEPTOR PROTEIN TYROSINE PHOSPHATASE DURING DIFFERENTIATION OF P19 EMBRYONAL CARCINOMA-CELLS

被引：36

作者：

DENHERTOG, J

PALS, CEGM

JONK, LJC

KRUIJER, W

机构：

[1] Hubrecht Laboratory, The Netherlands Institute for Developmental Biology, 3584 CT Utrecht

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 184卷 / 03期

关键词：

D O I：

10.1016/S0006-291X(05)80015-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein phosphorylation on tyrosine residues is one of the major mechanisms of cell signal transduction and is regulated by protein tyrosine kinases and protein tyrosine phosphatases. Here we report the molecular cloning of an additional member of the protein tyrosine phosphatase-family from differentiated murine P19 embryonal carcinoma cells. This non-receptor protein tyrosine phosphatase, P19-PTP, does not contain regulatory sequences, homologous to the ones found in other non-receptor PTPases. P19-PTP is differentially expressed during in vitro differentiation of P19 EC cells, in that P19-PTP mRNA could only be detected in embryoid bodies, derived from P19 cells. © 1992 Academic Press, Inc.

引用

页码：1241 / 1249

页数：9

共 31 条

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