PERACID CLEAVAGE OF 5-METHYLTETRAHYDROFOLIC ACID AT THE C9-N10 BRIDGE

被引：14

作者：

BAUGH, CM

BRAVERMAN, EB

NAIR, MG

HORNE, DW

BRIGGS, WT

WAGNER, C

机构：

[1] VANDERBILT UNIV,DEPT BIOCHEM,NASHVILLE,TN 37232

[2] VET ADM HOSP,NASHVILLE,TN 37203

来源：

ANALYTICAL BIOCHEMISTRY | 1979年 / 92卷 / 02期

关键词：

D O I：

10.1016/0003-2697(79)90672-9

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

5-Methyltetrahydrofolate cannot be cleaved at the C9N10 bond by the zinc/HCl reductive or the permanganate oxidative cleavage methods. A new method has been developed to perform this cleavage, using peracetic acid in 50% trifluoroacetic acid; the cleavage is quantitative and nondestructive of γ-glutamyl peptide bonds. © 1979.

引用

页码：366 / 369

页数：4

共 11 条

[1] IDENTIFICATION OF POLY-GAMMA-GLUTAMYL CHAIN LENGTHS IN BACTERIAL FOLATES
BAUGH, CM
BRAVERMAN, E
NAIR, MG
[J]. BIOCHEMISTRY, 1974, 13 (24) : 4952 - 4957
[2] BAUGH CM, 1971, ANN NY ACAD SCI, V186, P7
[3] IDENTIFICATION OF FORMS OF FOLATE FOUND IN LIVER, KIDNEY AND INTESTINE OF MONKEY AND THEIR BIOSYNTHESIS FROM EXOGENOUS PTEROYLGLUTAMATE (FOLIC-ACID)
BROWN, JP
DAVIDSON, GE
SCOTT, JM
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1974, 343 (01) : 78 - 88
[4] DIETS TL, 1975, CHEM BIOL PTERIDINES, P525
[5] DONALDSON KO, 1967, J BIOL CHEM, V237, P3815
[6] PREPARATION AND PROPERTIES OF CRYSTALLINE 5-METHYL TETRAHYDROFOLATE AND RELATED COMPOUNDS
GUPTA, VS
HUENNEKENS, FM
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1967, 120 (03) : 712 - +
[7] IDENTIFICATION OF PTEROYLPENTAGLUTAMATE AS MAJOR FOLATE DERIVATIVE IN RAT-LIVER AND DEMONSTRATION OF ITS BIOSYNTHESIS FROM EXOGENOUS [H-3] PTEROYLGLUTAMATE
HOULIHAN, CM
SCOTT, JM
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1972, 48 (06) : 1675 - &
[8] KALLEN RG, 1966, J BIOL CHEM, V241, P5845
[9] OXIDATIVE CLEAVAGE OF FOLATES - CRITICAL STUDY
MARUYAMA, T
SHIOTA, T
KRUMDIECK, CL
[J]. ANALYTICAL BIOCHEMISTRY, 1978, 84 (01) : 277 - 295
[10] SCOTT JM, 1977, FOLIC ACID BIOCH PHY, P43

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