CIRCULAR-DICHROISM STUDY OF THE SOLUTION CONFORMATION OF LUTEINIZING-HORMONE RELEASING HORMONE

被引：11

作者：

CANN, JR ^{[1
]}

CHANNABASAVAIAH, K ^{[1
]}

STEWART, JM ^{[1
]}

机构：

[1] UNIV COLORADO, DEPT BIOCHEM, DENVER, CO 80262 USA

来源：

BIOCHEMISTRY | 1979年 / 18卷 / 26期

关键词：

D O I：

10.1021/bi00593a005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A systematic investigation has been made into the circular dichroic behavior of luteinizing hormone releasing hormone and its peptide fragments and deletion analogues. The results are interpreted to mean that the hormone exists in solution as an ensemble of conformers with different sensitivities to temperature and solvent composition. The far-ultraviolet circular dichroic spectra exhibited by the hormone under different experimental conditions can be simulated satisfactorily by the weighted addition of the spectra of its aliphatic- and aromatic-containing halves. However, the structure of the hormone is not simply the sum of its halves, since some conformational feature of the intact molecule perturbs the near-ultraviolet circular dichroism of its aromatic residues. © 1979, American Chemical Society. All rights reserved.

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页码：5776 / 5781

页数：6

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