CANNABINOID RECEPTOR AGONISTS INHIBIT CA CURRENT IN NG108-15 NEUROBLASTOMA-CELLS VIA A PERTUSSIS TOXIN-SENSITIVE MECHANISM

被引：217

作者：

CAULFIELD, MP

BROWN, DA

机构：

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1992年 / 106卷 / 02期

关键词：

CANNABINOID; G-PROTEIN; PERTUSSIS TOXIN; CALCIUM CURRENT; NEUROBLASTOMA;

D O I：

10.1111/j.1476-5381.1992.tb14321.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cannabinoid receptor ligands irreversibly inhibited peak voltage-activated Ca currents (44%) in NG108-15 cells; this inhibition was Pertussis toxin-sensitive. Inhibition was largely due to a reduction in the omega-conotoxin sensitive portion of high-voltage activated (HVA) current, although there was also a significant decrease in low-voltage activated current (56%) and in the nifedipine-sensitive portion of HVA current (41%).

引用

页码：231 / 232

页数：2

共 9 条

[1] CAULFIELD MP, 1992, IN PRESS PFLUGERS AR
[2] NORADRENALINE-INDUCED INHIBITION OF VOLTAGE-SENSITIVE CALCIUM CURRENTS IN NG108-15 HYBRID-CELLS
DOCHERTY, RJ
MCFADZEAN, I
[J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 1989, 1 (02) : 132 - 140
[3] SELECTIVE COUPLING OF DIFFERENT MUSCARINIC ACETYLCHOLINE-RECEPTORS TO NEURONAL CALCIUM CURRENTS IN DNA-TRANSFECTED CELLS
HIGASHIDA, H
HASHII, M
FUKUDA, K
CAULFIELD, MP
NUMA, S
BROWN, DA
[J]. PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 1990, 242 (1303) : 68 - 74
[4] THE CANNABINOID RECEPTOR - BIOCHEMICAL, ANATOMICAL AND BEHAVIORAL CHARACTERIZATION
HOWLETT, AC
BIDAUTRUSSELL, M
DEVANE, WA
MELVIN, LS
JOHNSON, MR
HERKENHAM, M
[J]. TRENDS IN NEUROSCIENCES, 1990, 13 (10) : 420 - 423
[5] STRUCTURE OF A CANNABINOID RECEPTOR AND FUNCTIONAL EXPRESSION OF THE CLONED CDNA
MATSUDA, LA
LOLAIT, SJ
BROWNSTEIN, MJ
YOUNG, AC
BONNER, TI
[J]. NATURE, 1990, 346 (6284) : 561 - 564
[6] ANTIBODIES TO THE GTP BINDING-PROTEIN, G0, ANTAGONIZE NORADRENALINE-INDUCED CALCIUM CURRENT INHIBITION IN NG108-15 HYBRID-CELLS
MCFADZEAN, I
MULLANEY, I
BROWN, DA
MILLIGAN, G
[J]. NEURON, 1989, 3 (02) : 177 - 182
[7] NORADRENALINE-INDUCED AND ENKEPHALIN-INDUCED INHIBITION OF VOLTAGE-SENSITIVE CALCIUM CURRENTS IN NG108-15 HYBRID-CELLS - TRANSDUCTION MECHANISMS
MCFADZEAN, I
DOCHERTY, RJ
[J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 1989, 1 (02) : 141 - 147
[8] IDENTIFICATION OF 2 DISTINCT ISOFORMS OF THE GUANINE-NUCLEOTIDE BINDING PROTEIN-G0 IN NEUROBLASTOMA X GLIOMA HYBRID-CELLS - INDEPENDENT REGULATION DURING CYCLIC AMP-INDUCED DIFFERENTIATION
MULLANEY, I
MILLIGAN, G
[J]. JOURNAL OF NEUROCHEMISTRY, 1990, 55 (06) : 1890 - 1898
[9] ASPECTS OF VERTEBRATE NEURONAL VOLTAGE-ACTIVATED CALCIUM CURRENTS AND THEIR REGULATION
SCOTT, RH
PEARSON, HA
DOLPHIN, AC
[J]. PROGRESS IN NEUROBIOLOGY, 1991, 36 (06) : 485 - 520

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