GRANZYME-A - IMMUNOREACTIVE CELLS IN SYNOVIAL-FLUID IN REACTIVE AND RHEUMATOID-ARTHRITIS

被引：9

作者：

NORDSTROM, DC

KONTTINEN, YT

SORSA, T

NYKANEN, P

PETTERSSON, T

SANTAVIRTA, S

TSCHOPP, J

机构：

[1] Fourth Department of Medicine, Helsinki University Central Hospital, Helsinki, SF-00170

[2] Institute of Molecular Immunology, Hospital for Joint Diseases, NYU Medical School, New York, NY

[3] Inflammation Research Group, Department of Anatomy and Department of Periodontology, Helsinki University and Helsinki University Central Hospital, Helsinki

[4] University of Lausanne, Lausanne

来源：

CLINICAL RHEUMATOLOGY | 1992年 / 11卷 / 04期

关键词：

REACTIVE ARTHRITIS; RHEUMATOID ARTHRITIS; CYTOTOXIC T-CELLS; PERFORIN;

D O I：

10.1007/BF02283113

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Perforin and granzyme A co-localize in the cytotoxic granules of killer cells like cytotoxic T lymphocytes (CTL). Perforin is the cytolytic pore-forming protein, whereas the function of the homodimeric serine protease granzyme A and other members of the granzyme family is still unclear. Granzyme A - immunoreactive cells formed 8 +/- 2% of the resting peripheral blood lymphocytes of healthy individuals. In contrast, granzyme A-positive cells formed 15% of peripheral blood mononuclear cells in patients with reactive or rheumatoid arthritis. However, 29 +/- 4% (p < 0.05 compared to normal peripheral blood) and 25 +/- 4% (p < 0.05) of all lymphocytes in synovial fluid in reactive and rheumatoid arthritis, respectively, were granzyme A - positive. This suggests involvement of cell-mediated cytolytic mechanisms in the articular pathogenic mechanisms. This involvement, however, does not differentiate between reactive and rheumatoid arthritis.

引用

页码：529 / 532

页数：4

共 35 条

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