MODULATION OF IGF-2 EXPRESSION DURING GROWTH AND DIFFERENTIATION OF HUMAN NEUROBLASTOMA-CELLS - RETINOIC ACID MAY INDUCE IGF-2

被引：30

作者：

MELINO, G

STEPHANOU, A

ANNICCHIARICOPETRUZZELLI, M

KNIGHT, RA

FINAZZIAGRO, A

LIGHTMAN, SL

机构：

[1] IRCCS IDI,ROME,ITALY

[2] CHARING CROSS WESTMINSTER MED SCH,LONDON,ENGLAND

[3] BROMPTON HOSP,DEPT CYST FIBROSIS,LONDON SW3 6HP,ENGLAND

来源：

NEUROSCIENCE LETTERS | 1993年 / 151卷 / 02期

关键词：

NEUROBLASTOMA; IGF-2; GHRH; RETINOIC ACID; DIFFERENTIATION; APOPTOSIS; PROGRAMMED CELL DEATH;

D O I：

10.1016/0304-3940(93)90017-F

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Insulin-like growth factor 2 (IGF-2) is the major autocrine growth factor for neuroblastoma. IGF-2 mRNA can just be detected in SK-N-BE(2) cell line; higher levels are present in two clones derived from it [BE(2)-C; BE(2)-M17]. IGF-2 mRNA is increased by retinoic acid (RA) only in the clones. IGF-2 expression/induction is more marked in BE(20-M17, which shows more RA-resistance (evaluated as growth inhibition, neurite outgrowth and induction of programmed cell death). Under RA exposure, the parental line shows a more pronounced growth inhibition, neurite outgrowth and programmed cell death, as compared to its clones. BE(2)-C cells also express type 1 IGF receptor mRNA, though with a different time course than for expression of IGF-2. The data suggest that IGF-2 expression is correlated with growth, and may counteract the growth retardation, neurite outgrowth and programmed cell death effects of retinoic acid. Therefore the autocrine pattern of IGF-2 production by neuroblastoma cells may promote RA-resistance.

引用

页码：187 / 191

页数：5

共 24 条

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