ORAL IRON-CHELATING THERAPY - THE L1 EXPERIENCE

被引:14
作者
ALREFAIE, FN
HOFFBRAND, AV
机构
来源
BAILLIERE'S CLINICAL HAEMATOLOGY, VOL 7, NO 4, DECEMBER 1994 | 1994年 / 7卷 / 04期
关键词
D O I
10.1016/S0950-3536(05)80132-5
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
L1 is the most widely studied oral iron-chelating drug and at present the only one shown to be effective at causing negative iron balance in long-term clinical trials for thalassaemia major and other transfusion-dependent refractory anaemias. Because of side-effects, both in experimental animals and in humans, its development as a widely available pharmaceutical agent has been delayed. However, for the large numbers of transfusion-dependent, iron-overloaded patients who do not use DFX because of poor compliance, adverse effects or unavailability of the drug, L1 may be a suitable alternative for iron chelation. However, its use should be restricted to Ethical Committee approved clinical trials. Patients who are capable of using DFX effectively should be encouraged to continue doing so until an oral iron chelator has been fully established for clinical use. It is hoped that 3-hydroxypyrid-4-one analogues of L1 as well as compounds related to pyridoxal isonicotinyl hydrazone, HBED or hydroxamic acid can be found both orally effective and safe for long-term administration. Current and future trials of L1 could address some of the following issues, beside extending present studies on the efficacy and adverse effects of L1:o1.The effect of administering a reduced dose of L1 (<75 mg/kg per day) on the incidence of adverse effects and on long-term efficacy.2.The efficacy and adverse effects of L1 at a low dose in patients with non-transfusional iron overload such as thalassaemia intermedia, primary haemochromatosis and congenital haemolytic anaemias.3.The effect of combining oral L1 with intravenous or subcutaneous DFX on the incidence of adverse effects and efficacy.4.Elucidation of the mechanisms involved in agranulocytosis and joint toxicity and finding methods to predict for individual susceptibility to these adverse effects and ways of preventing them. © 1994 Baillière Tindall All rights reserved.
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页码:941 / 963
页数:23
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