THEOPHYLLINE, A NEW INDUCER OF APOPTOSIS IN B-CLL - ROLE OF CYCLIC-NUCLEOTIDES

被引：48

作者：

MENTZ, F

MERLEBERAL, H

OUAAZ, F

BINET, JL

机构：

[1] HOP LA PITIE SALPETRIERE,DEPT HEMATOL,HEMATOIMMUNOL MOLEC GRP,CNRS,URA 625,F-75013 PARIS,FRANCE

[2] HOP LA PITIE SALPETRIERE,UNITE CLAUDE BERNARD C20,PARIS,FRANCE

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1995年 / 90卷 / 04期

关键词：

B-CLL; APOPTOSIS; THEOPHYLLINE; CAMP;

D O I：

10.1111/j.1365-2141.1995.tb05225.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a case of indolent B-chronic lymphocytic leukaemia (B-CLL) in a stage A patient, treated for 10 years only by theophylline for bronchial asthma. As suggested by the spontaneous apoptosis in the patient's blood (10%), theophylline at 50 mu g/ml increased spontaneous apoptosis after 72 h in culture by a mean percentage of 90% (range 79-98%) in six B-CLL cases studied in vitro. This effect was partially reversed with Rp-cAMP, a cAMP antagonist, which implies a potent role for this second messenger. We describe a new property of theophylline, which might be an alternative treatment in B-CLL.

引用

页码：957 / 959

页数：3