ISOLATION BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AND QUANTITATION BY RADIOIMMUNOASSAY OF THERAPEUTIC CONCENTRATIONS OF DIGOXIN AND METABOLITES

被引：37

作者：

NELSON, HA

LUCAS, SV

GIBSON, TP

机构：

[1] Veterans Administration Lakeside Hospital, General Medical Research Service, Chicago, IL 60611

来源：

JOURNAL OF CHROMATOGRAPHY | 1979年 / 163卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0378-4347(00)81460-7

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A method combining high-performance liquid chromatography for separation of digoxin from three of its metabolites with subsequent quantitation of each compound by radioimmunoassay is described. The metabolites are shown to interfere with the radioimmunoassay procedure thus providing the need for separation prior to assay. © 1979.

引用

页码：169 / 177

页数：9

共 6 条

[1] ISOLATION AND QUANTITATION OF PICOMOLE QUANTITIES OF DIGOXIN, DIGITOXIN AND THEIR METABOLITES BY HIGH-PRESSURE LIQUID-CHROMATOGRAPHY
CASTLE, MC
[J]. JOURNAL OF CHROMATOGRAPHY, 1975, 115 (02): : 437 - 445
[2] PHARMACOKINETICS OF DIGOXIN IN NORMAL SUBJECTS AFTER INTRAVENOUS BOLUS AND INFUSION DOSES
KOUP, JR
GREENBLATT, DJ
JUSKO, WJ
SMITH, TW
KOCHWESER, J
[J]. JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1975, 3 (03): : 181 - 192
[3] KOUP JR, 1975, CLIN PHARMACOL THER, V18, P9
[4] PHARMACOKINETICS OF DIGOXIN - COMPARISON OF A 2-COMPARTMENT AND A 3-COMPARTMENT MODEL IN MAN
KRAMER, WG
LEWIS, RP
COBB, TC
FORESTER, WF
VISCONTI, JA
WANKE, LA
BOXENBAUM, HG
REUNING, RH
[J]. JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1974, 2 (04): : 299 - 312
[5] RODBARD D, 1969, J LAB CLIN MED, V74, P770
[6] STOLL RG, 1972, RES COMMUN CHEM PATH, V4, P503

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