CYCLIC ADENOSINE-3',5'-MONOPHOSPHATE AND THE MECHANISM OF ACTION OF 3 COMMON ANTI-INFLAMMATORY DRUGS

被引：14

作者：

DEPORTER, DA ^{[1
]}

DUNN, CJ ^{[1
]}

WILLOUGHBY, DA ^{[1
]}

机构：

[1] ST BARTHOLOMEWS HOSP,DEPT EXPTL PATHOL,LONDON EC1,ENGLAND

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1979年 / 65卷 / 02期

关键词：

D O I：

10.1111/j.1476-5381.1979.tb07814.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of indomethacin, dexamethasone and colchicine on cyclic adenosine 3′, 5′‐monophosphate (cyclic AMP) concentration in leucocytes during a crystal‐induced pleurisy in rats were studied. Each of the drugs significantly increased leucocyte cyclic AMP content within 3 h of the injection of crystals. By 6 h, leucocyte cyclic AMP levels were returning toward control levels and could not be sustained at the higher level by an additional administration of the respective anti‐inflammatory drug. 1979 British Pharmacological Society

引用

页码：163 / 165

页数：3

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