THE ROLE OF PH IN SALIVARY HISTIDINE-RICH POLYPEPTIDE ANTIFUNGAL GERM TUBE INHIBITORY ACTIVITY

被引：17

作者：

BRANT, EC ^{[1
]}

SANTARPIA, RP ^{[1
]}

POLLOCK, JJ ^{[1
]}

机构：

[1] SUNY STONY BROOK,SCH DENT MED,DEPT ORAL BIOL & PATHOL,STONY BROOK,NY 11794

来源：

ORAL MICROBIOLOGY AND IMMUNOLOGY | 1990年 / 5卷 / 06期

关键词：

antifungal; Candida albicans; histidine‐rich polypeptide; saliva;

D O I：

10.1111/j.1399-302X.1990.tb00437.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Purified synthetic salivary histidine‐rich polypeptides (HRPs) 2, 3, 4, 5 and 6 were found to inhibit Candida albicans conversion of blastospores to germ tubes. HRP‐4 was the best inhibitor within the pH 5 to 7 range tested and all of the HRPs were observed to lose potency as the pH was raised from 5 to 7. The pH pattern obtained with a synthetic homologous histidine peptide suggested that the protonated form of the histidine imidazole residues of the HRPs was important to the germ tube antifungal activity. Similar pH inhibition profiles of germ tube formation by parotid saliva and the HRPs were also observed. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：336 / 339

页数：4

共 25 条

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