EFFECTS EVOKED BY PENTAMETHYLENETETRAZOL-INDUCED SEIZURES UPON N-ACETYLASPARTATE AND N-ACETYLASPARTYLGLUTAMATE LEVELS IN DIFFERENT REGIONS OF THE RAT NEURAXIS

被引：6

作者：

BRANCATI, A

DARCANGELO, P

机构：

[1] UNIV TOR VERGATA, DEPT EXPTL MED & BIOCHEM SCI, ROME, ITALY

[2] UNIV ROME LA SAPIENZA, INST HUMAN PHYSIOL, I-00185 ROME, ITALY

来源：

LIFE SCIENCES | 1991年 / 48卷 / 23期

关键词：

D O I：

10.1016/0024-3205(91)90337-B

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We have examined the effects evoked by pentamethylenetetrazol (PTZ)-induced seizures upon the concentration of N-acetylaspartate (NAA) and of N-acetylaspartylglutamate (NAAG) in the forebrain, brainstem and spinal cord of rats. We observed a significant decrease of both NAA and NAAG in each one of the studied regions. These findings are consistent with an inhibitory role proposed in CNS for NAA and NAAG.

引用

页码：2229 / 2232

页数：4

共 19 条

[1] Avoli M, 1976, Boll Soc Ital Biol Sper, V52, P1525
[2] BLAKELY RD, 1988, INT REV NEUROBIOL, V30, P39
[3] PARTICIPATION OF N-ACETYL-L-ASPARTIC ACID IN BRAIN METABOLISM
BUNIATIAN, HC
HOVHANNISSIAN, VS
APRIKIAN, GV
[J]. JOURNAL OF NEUROCHEMISTRY, 1965, 12 (08) : 695 - +
[4] DISTRIBUTION OF N-ACETYL-ASPARTIC AND N-ACETYL-ASPARTYL-GLUTAMIC ACIDS IN NERVOUS TISSUE
CURATOLO, A
DARCANGE.P
LINO, A
BRANCATI, A
[J]. JOURNAL OF NEUROCHEMISTRY, 1965, 12 (04) : 339 - &
[5] CURATOLO A, 1967, ARCH SCI BIOL, V51, P98
[6] CURATOLO A, 1964, 6 INT C BIOCH NEW YO
[7] CURATOLO A, 1967, B SOC ITAL BIOL SPER, V43, pP264
[8] D'Arcangelo P, 1970, Arch Fisiol, V67, P288
[9] DISTRIBUTION OF N-ACETYLASPARTATE, N-ACETYLASPARTYLGLUTAMATE, FREE GLUTAMATE AND ASPARTATE FOLLOWING COMPLETE MESENCEPHALIC TRANSECTION IN RAT NEURAXIS
DARCANGELO, P
BRANCATI, A
[J]. NEUROSCIENCE LETTERS, 1990, 114 (01) : 82 - 88
[10] DARCANGELO P, 1964, B SOC ITAL BIOL SPER, V40, P2197

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