EFFECTS OF PHENYTOIN IN 2 MYOTONIC HORSES WITH HYPERKALEMIC PERIODIC PARALYSIS

被引：25

作者：

BEECH, J ^{[1
]}

FLETCHER, JE ^{[1
]}

TRIPOLITIS, L ^{[1
]}

LINDBORG, S ^{[1
]}

机构：

[1] HAHNEMANN UNIV,DEPT ANESTHESIOL,PHILADELPHIA,PA 19102

来源：

MUSCLE & NERVE | 1992年 / 15卷 / 08期

关键词：

CALCIUM RELEASE; HYPERKALEMIC PERIODIC PARALYSIS; MYOTONIA; PHENYTOIN;

D O I：

10.1002/mus.880150811

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The effects of phenytoin treatment were evaluated in 2 myotonic horses with hyperkalemic periodic paralysis (HPP). Phenytoin treatment abolished the clinical signs of muscle fasciculations following oral potassium challenge and decreased or abolished repetitive firing and myotonic discharges found on electromyographic examination. In both horses, an abnormally low threshold for calcium-induced calcium release was measured in heavy sarcoplasmic reticulum fractions from skeletal muscle, and this threshold increased with phenytoin treatment. Results suggest phenytoin is useful in modifying disordered ion regulation in the sarcolemma and sarcoplasmic reticulum of skeletal muscle in equine hyperkalemic periodic paralysis.

引用

页码：932 / 936

页数：5

共 32 条

[1]

BEECH J, 1988, AM J VET RES, V49, P2130

[2]

BEECH J, 1990, FASEB J, V4, pA1209

[3] A SODIUM-CHANNEL DEFECT IN HYPERKALEMIC PERIODIC PARALYSIS - POTASSIUM-INDUCED FAILURE OF INACTIVATION [J].