MICROBIOLOGICAL PROPERTIES OF PROTOANEMONIN ISOLATED FROM RANUNCULUS-BULBOSUS

被引：60

作者：

DIDRY, N ^{[1
]}

DUBREUIL, L ^{[1
]}

PINKAS, M ^{[1
]}

机构：

[1] FAC PHARM LILLE,BACTERIOL LAB,F-59006 LILLE,FRANCE

来源：

PHYTOTHERAPY RESEARCH | 1993年 / 7卷 / 01期

关键词：

PROTOANEMONIN; ANTIMICROBIALS; ANTIBIOTICS; COMBINATIONS;

D O I：

10.1002/ptr.2650070107

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The antimicrobial properties of protoanemonin isolated from the aerial parts of Ranunculus bulbosus were investigated. By its marked inhibitory effects and its broad spectrum of activity against aerobes and anaerobes including multiresistant pathogenic strains, protoanemonin could be considered as a promising antimicrobial natural compound. Combinations of protoanemonin and antibiotics were also investigated. Twenty two antibiotic-protoanemonin combinations against aerobic bacteria were studied: 20 combinations were partially synergistic (0.5 < FIC less-than-or-equal-to 0.75) and in one case a total synergism (FIC less-than-or-equal-to 0.5) was observed. This striking result was obtained with the protoanemonin-cefamandole combination against a pathogenic strain of Staphylococcus aureus.

引用

页码：21 / 24

页数：4

共 22 条

[1]

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[2]

BERNARD SM, 1960, P INDIANA ACAD SCI, V70, P83

[3] AN HPLC SCREENING OF SOME ITALIAN RANUNCULACEAE FOR THE LACTONE PROTOANEMONIN [J].