TRICYCLIC BRIDGED BETA-LACTAMS AS TRANSITION-STATE ANALOGS - A STUDY USING SEMIEMPIRICAL MOLECULAR-ORBITAL METHODS

被引：6

作者：

BRUTON, G

机构：

[1] SmithKline Beecham Pharmaceuticals, Department of Medicinal Chemistry, Betchworth, Surrey England, Brockham Park

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(01)80949-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The effect of ring strain on nitrogen pyramidality and carboxylate orientation was measured for six novel beta-lactam nuclei using both the AMI and PM3 methods within MOPAC. Comparison with X-ray data resulted in novel carba -cephem and -penem nuclei being proposed as transition state analogues of peptide hydrolysis.

引用

页码：2329 / 2332

页数：4

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