TARGET FACTOR MODELING OF MIGRATION BEHAVIOR IN CAPILLARY ELECTROPHORESIS

被引：14

作者：

SAHOTA, RS ^{[1
]}

KHALEDI, MG ^{[1
]}

机构：

[1] N CAROLINA STATE UNIV,DEPT CHEM,RALEIGH,NC 27695

来源：

ANALYTICAL CHEMISTRY | 1994年 / 66卷 / 14期

关键词：

D O I：

10.1021/ac00086a025

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This paper describes a target factor analysis based technique to model migration behavior in capillary electrophoresis (CE). The technique is effective in reducing the initial number of experiments required for modeling, as well as in recognizing the optimum conditions for running these experiments. The technique can be applied to optimize any number of parameters. The usefulness of the technique is demonstrated via both the experimentally obtained and the simulated data sets. Examples are provided to describe optimization of one and two parameters.

引用

收藏

页码：2374 / 2381

页数：8

相关论文

共 24 条

[1] APPLICATION OF TARGET FACTOR-ANALYSIS TO GAS-CHROMATOGRAPHY - REPRODUCTION, PREDICTION AND CLASSIFICATION [J].

BERGMAN, G ;

GOTZE, HJ ;

HERMANN, A ;

ZINN, P .

CHROMATOGRAPHIA, 1991, 32 (5-6) :259-264

[2] ELECTROPHORESIS - MATHEMATICAL-MODELING AND COMPUTER-SIMULATION [J].

BIER, M ;

PALUSINSKI, OA ;

MOSHER, RA ;

SAVILLE, DA .

SCIENCE, 1983, 219 (4590) :1281-1287

[3] MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY THEORY BASED ON ELECTROCHEMICAL PARAMETERS - OPTIMIZATION FOR 3 MODES OF OPERATION [J].

GHOWSI, K ;

FOLEY, JP ;

GALE, RJ .

ANALYTICAL CHEMISTRY, 1990, 62 (24) :2714-2721

[4] A SEMIEMPIRICAL MODEL FOR THE ELECTROPHORETIC MOBILITIES OF PEPTIDES IN FREE-SOLUTION CAPILLARY ELECTROPHORESIS [J].

GROSSMAN, PD ;

COLBURN, JC ;

LAUER, HH .

ANALYTICAL BIOCHEMISTRY, 1989, 179 (01) :28-33

[5] HIGH-SPEED ELECTROPHORESIS SIMULATION FOR OPTIMIZATION OF CONTINUOUS-FLOW ELECTROPHORESIS AND HIGH-PERFORMANCE CAPILLARY TECHNIQUES .1. COMPUTER-MODEL [J].

HEINRICH, J ;

WAGNER, H .

ELECTROPHORESIS, 1992, 13 (1-2) :44-49

[6] PREDICTING RETENTION DATA BY TARGET FACTOR-ANALYSIS AND MULTIPLE-REGRESSION ANALYSIS [J].

HOWERY, DG ;

WILLIAMS, GD ;

AYALA, N .

ANALYTICA CHIMICA ACTA, 1986, 189 (02) :339-351

[7] PREDICTION OF PARTITION-COEFFICIENTS IN TERNARY LIQUID-LIQUID SYSTEMS AS A FUNCTION OF THE PHASE SYSTEM COMPOSITION BY FACTOR-ANALYSIS FOR CHROMATOGRAPHY [J].

HUBER, JFK ;

WELTE, S ;

REICH, G .

ANALYTICA CHIMICA ACTA, 1985, 177 :1-14

[8] MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY OF ACIDIC SOLUTES - MIGRATION BEHAVIOR AND OPTIMIZATION STRATEGIES [J].

KHALEDI, MG ;

SMITH, SC ;

STRASTERS, JK .

ANALYTICAL CHEMISTRY, 1991, 63 (17) :1820-1830

[9]

KHALEDI MG, 1993, CAPILLARY ELECTROPHO

[10] OPTIMIZATION OF SENSITIVITY AND SEPARATION IN CAPILLARY ZONE ELECTROPHORESIS WITH INDIRECT FLUORESCENCE DETECTION [J].

KUHR, WG ;

YEUNG, ES .

ANALYTICAL CHEMISTRY, 1988, 60 (23) :2642-2646